TABLE 3

Logistic regression model of treatment to A1C target

420del
R61C
ORPORP
Genotype0.9780.83071.1630.3554
Baseline A1C0.748<0.00010.747<0.0001
Creatinine clearance0.5240.00030.5230.0002
Average dose0.9790.17260.9790.1690
Adherence1.1340.00061.1340.0006
Group0.448<0.00010.448<0.0001
  • The coefficients are for the average dose per 100 mg, for creatinine clearance per 100 ml/min, and for adherence per 10% change. The genotypes were coded as the dosage of mutant alleles. OR, odds ratio.