TABLE 1

Incidence of pancreatitis, ductal metaplasia, and increased ductal turnover by group

Wild typeHIPHIP + SITHIP + METHIP + SIT + MET
Number studied78898
Pancreatitis00100
Ductal metaplasia00201
Increased ductal proliferation*4821
  • Data are n.

  • *Increase in ductal cell proliferation was defined as an increase in ductal proliferation 3 SDs above the mean of wild-type rats. HIP + MET, HIP rats treated with metformin; HIP + SIT, HIP rats treated with sitagliptin; HIP + SIT + MET, HIP rats treated with combination therapy.