TABLE 2

Associations of KCNQ1 SNPs rs151290, rs2237892, rs2237895, and rs2237897 with anthropometric and metabolic traits

rs151290 (0.208)
rs2237892 (0.064)
rs2237895 (0.427)
rs2237897 (0.037)
CCCAAAPaddPdomCCAATTPaddPdomAAACCCPaddPdomCCCTTTPaddPdom
n995508751,384183105217652921,4631113
Age (years)39 ± 1340 ± 1438 ± 140.50.740 ± 1339 ± 1434 ± 120.40.539 ± 1340 ± 1339 ± 140.00910.0540 ± 1338 ± 1537 ± 150.20.11
BMI (kg/m2)28.7 ± 8.129.1 ± 8.529.1 ± 7.30.60.428.8 ± 8.329.1 ± 7.731.2 ± 6.60.30.329.2 ± 8.129.0 ± 8.527.8 ± 7.60.02520.0828.8 ± 8.229.6 ± 8.134.7 ± 6.80.160.15
Waist circum-ference (cm)93 ± 1795 ± 1895 ± 170.40.1794 ± 1794 ± 1799 ± 150.40.494 ± 1794 ± 1892 ± 170.090.1094 ± 1795 ± 17103 ± 230.20.13
Body fat (%)30.7 ± 10.831.4 ± 11.031.9 ± 11.00.20.330.8 ± 10.932.0 ± 10.732.8 ± 8.70.170.231.6 ± 10.830.8 ± 11.030.5 ± 10.50.170.0730.9 ± 10.832.6 ± 11.038.3 ± 5.20.190.4
Fasting glucose (mmol/l)5.11 ± 0.565.09 ± 0.525.15 ± 0.540.50.65.10 ± 0.555.12 ± 0.525.05 ± 0.520.04570.75.09 ± 0.545.10 ± 0.535.13 ± 0.610.90.85.11 ± 0.555.07 ± 0.545.45 ± 0.710.60.7
Glucose: 120-min OGTT (mmol/l)6.32 ± 1.666.14 ± 1.646.52 ± 1.640.00350.03036.26 ± 1.656.31 ± 1.666.96 ± 2.200.01210.146.18 ± 1.636.27 ± 1.666.41 ± 1.700.50.66.26 ± 1.656.31 ± 1.727.39 ± 2.600.70.9
Fasting insulin (pmol/l)62.8 ± 48.864.2 ± 59.072.6 ± 61.30.130.562.6 ± 51.470.8 ± 62.5482.7 ± 67.00.180.765.4 ± 51.463.3 ± 55.761.8 ± 47.90.060.019862.9 ± 52.873.6 ± 54.4101 ± 48.50.110.0388
Insulin: 30-min OGTT (pmol/l)477 ± 369512 ± 416584 ± 5080.180.2480 ± 379589 ± 473565 ± 4330.00270.0010528 ± 424487 ± 380449 ± 3620.180.08484 ± 384616 ± 486592 ± 3680.120.09
First-phase insulin secretion (pmol/l)1,235 ± 7821,322 ± 9061,433 ± 1,0850.02030.00721,245 ± 8111,470 ± 1,0241,445 ± 9000.120.111,343 ± 8991,250 ± 8241,205 ± 7710.090.04101,253 ± 8241,532 ± 1,0271,536 ± 5260.20.10
Insulinogenic index (pmol/mmol)137 ± 398157 ± 174160 ± 1420.02460.0104140 ± 350174 ± 160136 ± 680.140.0472171 ± 263126 ± 413144 ± 1530.060.0409145 ± 323136 ± 443139 ± 420.40.3
C-peptidesum 0–10 min IVGTT (pmol/l)*8,357 ± 3,5448,355 ± 3,3219,508 ± 7,5340.90.88,299 ± 3,4239,189 ± 5,6240.90.98,776 ± 4,6468,208 ± 3,3138,432 ± 3,4260.50.48,286 ± 3,39910772 ± 7,9040.40.4
ISI: OGTT (U)16.3 ± 10.716.6 ± 10.914.3 ± 9.60.03300.416.6 ± 10.914.5 ± 9.215.0 ± 14.50.31.016.1 ± 10.716.3 ± 10.816.6 ± 10.70.080.024516.5 ± 10.814.4 ± 10.59.3 ± 8.20.100.0340
ISI: clamp (U)0.089 ± 0.0600.080 ± 0.0470.068 ± 0.0270.30.140.087 ± 0.0550.075 ± 0.0560.1340.40.30.088 ± 0.0550.080 ± 0.0560.095 ± 0.0500.40.30.086 ± 0.0540.082 ± 0.0640.50.5
  • Data are means ± SD unless otherwise indicated. For statistical analysis, data were log transformed. Anthropometric data were adjusted for sex and age. Indexes of insulin sensitivity were adjusted for sex, age, and BMI. Indexes of insulin secretion were adjusted for sex, age, BMI, and insulin sensitivity. ISI, insulin sensitivity index; Padd, additive model; Pdom, dominant model.

  • *IVGTT data were available from 314 subjects.

  • †ISI (clamp) data were available from 519 subjects.