TABLE 3

Associations of KCNQ1 SNPs rs151290, rs2237892, rs2237895, and rs2237897 with the incretins GLP-1 and GIP

rs151290 (0.208)
rs2237892 (0.064)
rs2237895 (0.427)
rs2237897 (0.037)
CCCAAAPaddPdomCCCTTTPaddPdomAAACCCPaddPdomCCCTTTPaddPdom
n116478150210559224159120
GLP-1 (pmol/l)
    0 min18.1 ± 9.115.0 ± 7.115.9 ± 8.60.20.1017.2 ± 8.716.8 ± 9.00.90.916.1 ± 8.217.8 ± 8.916.8 ± 8.80.40.317.3 ± 8.815.5 ± 6.80.90.9
    30 min35.4 ± 19.141.7 ± 35.295 ± 170.70.536.9 ± 25.636.5 ± 14.90.40.431.9 ± 14.640.3 ± 28.734.5 ± 23.10.30.337.0 ± 25.034.1 ± 15.71.01.0
    120 min30.4 ± 13.529.0 ± 13.428.6 ± 9.30.40.1829.7 ± 13.729.8 ± 10.90.50.526.3 ± 12.331.4 ± 13.931.0 ± 13.00.150.0529.8 ± 13.729.3 ± 8.50.70.7
GIP (pmol/l)
    0 min15.5 ± 11.312.5 ± 7.312.1 ± 4.60.30.1214.8 ± 10.712.1 ± 5.70.60.616.4 ± 14.213.9 ± 7.812.5 ± 6.60.20.0914.7 ± 10.512.4 ± 5.20.80.8
    30 min84.5 ± 30.3101.2 ± 47.871.8 ± 28.40.100.1089.0 ± 37.184.7 ± 33.90.80.887.6 ± 31.790.1 ± 41.384.1 ± 27.40.80.588.1 ± 37.393.6 ± 27.10.50.5
    120 min71.4 ± 29.176.1 ± 35.360.1 ± 26.00.80.972.0 ± 31.173.3 ± 29.50.90.974.7 ± 34.270.2 ± 30.373.7 ± 24.80.70.871.8 ± 31.276.2 ± 26.90.50.5
  • Data are means ± SD unless otherwise indicated. For statistical analysis, data were log transformed. Incretin data were adjusted for sex, age, and BMI. Padd, additive model; Pdom, dominant model.