Gene SNP | Alleles MAF (%) | Proins_{0}/Ins_{0} | ProinsAUC_{0–30}/InsAUC_{0–30} | ProinsAUC_{30–120}/InsAUC_{30–120} | ProinsAUC_{0–120}/InsAUC_{0–120} | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect size B (SE) | P values | ^{*}P values | Effect size B (SE) | P values | ^{*}P values | Effect size B (SE) | P values | ^{*}P values | Effect size B (SE) | P values | ^{*}P values | ||
TCF7L2 rs7903146 | C/T 17.7 | 1.20 (1.22) | 0.042 | 0.021 | 0.75 (0.42) | 0.002 | 6.0E-04 | 0.55 (0.44) | 0.005 | 1.1E-03 | 0.57 (0.43) | 0.004 | 0.001 |
SLC30A8 rs13266634 | C/T 39.1 | 1.59 (0.96) | 0.006 | 0.003 | 0.73 (0.33) | 1.9E-05 | 1.2E-05 | 0.64 (0.35) | 1.1E-04 | 4.2E-05 | 0.64 (0.34) | 8.2E-05 | 2.8E-05 |
HHEX rs1111875 | C/T 46.9 | 0.74 (0.94) | 0.365 | 0.622 | 0.80 (0.32) | 9.7E-06 | 6.5E-06 | 0.69 (0.34) | 0.002 | 0.002 | 0.71 (0.33) | 0.001 | 6.6E-04 |
CDKAL1 rs7754840 | G/C 37.0 | −0.39 (0.98) | 0.313 | 0.775 | 0.32 (0.34) | 3.1E-04 | 0.001 | 0.36 (0.35) | 0.003 | 0.009 | 0.35 (0.35) | 0.002 | 0.005 |
Effect size shown is B-coefficient (SE) per copy of the type 2 diabetes risk allele and was calculated using untransformed variables adjusted for age by linear regression. P values were calculated using log-transformed variables (because of their skewed distribution) by linear regression. P values are adjusted for age;
*P values are adjusted for age, BMI, and Matsuda ISI. In the entire cohort, means ± SE of examined parameters and the number of subjects with available data were as follows: Proins_{0}/Ins_{0} 36.3 ± 0.67 (n = 2,712), ProinsAUC_{0–30}/InsAUC_{0–30} 12.5 ± 0.23 (n = 2,697), ProinsAUC_{30–120}/InsAUC_{30–120} 14.1 ± 0.24 (n = 2,693), ProinsAUC_{0–120}/InsAUC_{0–120} 13.8 ± 0.24 (n = 2,692). P values significant after correction for multiple testing (P < 6.9 × 10^{−4}) are in bold. Risk alleles are underlined. Results for the additive model are presented.