TABLE 3

Association analyses of the BMPR1A genetic variants with obesity in the Leipzig and the Sorbian cohorts

Major alleleMinor alleleLeipzig*
Sorbs
Combined analysis
Major allele frequency (case/control)OR (95% CI)PMajor allele frequency (case/control)OR (95% CI)POR (95% CI)P
rs7095025CT0.76/0.731.26 (1.02; 1.56)0.030.82/0.741.85 (1.25; 2.73)0.0021.29 (1.08; 1.54)0.004
rs11202222CG0.79/0.751.26 (1.02; 1.55)0.030.86/0.772.09 (1.38; 3.18)5.2 × 10−41.40 (1.16; 1.69)4.4 × 10−4
rs10788528GA0.86/0.821.40 (1.10; 1.78)0.0060.92/0.842.39 (1.45; 3.93)6.1 × 10−41.56 (1.27; 1.94)3.5 × 10−5
rs7922846AT0.73/0.701.22 (1.00; 1.48)0.050.77/0.721.21 (0.86; 1.71)0.271.23 (1.04; 1.46)0.016
  • P values were adjusted for age and sex. ORs indicate effect directions of the major allele in additive mode of inheritance. Combined ORs and P values represent the combined analysis of the two cohorts (Leipzig and Sorbs). The combined analyses were adjusted for age, sex, and study cohort.

  • *n = 752 case subjects (BMI >30 kg/m2) vs. 488 control subjects (BMI <25 kg/m2);

  • n = 210 case subjects vs. 303 control subjects.