TABLE 4

Association of BMPR1A obesity risk variants with quantitative traits in the Leipzig cohort

Minor allele frequencyBMI (kg/m2)WHRPlasma leptin (ng/ml)Fasting plasma glucose (mmol/l)Plasma glucose 120 min (mmol/l)Fasting plasma insulin (pmol/l)
rs70950250.26
    P0.0060.8400.0003/0.0020.441/0.5540.566/0.4570.859/0.436
    β0.0230.0020.358/0.2720.005/0.004−0.009/−0.0120.016/−0.065
    SE0.0080.0090.098/0.0870.007/0.0070.016/0.0160.091/0.084
rs112022220.22
    P0.0040.7300.009/0.0360.177/0.2440.804/0.6860.825/0.449
    β0.0250.0030.266/0.1900.009/0.008−0.004/−0.0070.021/−0.066
    SE0.0090.0100.102/0.090.007/0.0070.016/0.0160.094/0.087
rs107885280.16
    P0.0050.1980.101/0.2210.334/0.4230.872/0.7650.470/0.849
    β0.0280.0140.203/0.1340.008/0.006−0.003/−0.0060.077/−0.019
    SE0.0100.0110.124/0.1090.008/0.0080.019/0.0190.107/0.099
rs79228460.27
    P0.130.070.125/0.2390.290/0.3270.009/0.010.035/0.133
    β0.0120.0160.156/0.1050.007/0.0060.040/0.0390.190/0.125
    SE0.0080.0090.101/0.0890.006/0.0060.015/0.0150.090/0.083
  • Data represent subjects without type 2 diabetes (n = 966). Parameters were ln transformed before analyses. P values were adjusted for age and sex for all variables; for the variables serum leptin, fasting plasma glucose, fasting plasma insulin, and 2-h plasma glucose, the first P value was calculated after adjusting for age and sex and the second P value after adjusting for age, sex, and BMI. β indicates effect directions of the major allele in additive mode of inheritance.