TABLE 5

Association of BMPR1A obesity risk variants with quantitative traits in the Sorbian cohort

Minor allele frequencyBMI (kg/m2)WHRFasting plasma glucose (mmol/l)Plasma glucose 120 min (mmol/l)Fasting plasma insulin (pmol/l)
rs70950250.22
    P0.0070.3610.100/0.4550.350/0.6600.005/0.08
    β0.0270.0050.011/0.0050.019/0.0090.120/0.068
    SE0.0100.0050.006/0.0060.020/0.0200.042/0.038
    Combined β (95% CI)0.025 (0.012; 0.037)0.004 (−0.004; 0.013)0.005 (−0.004; 0.014)−0.004 (−0.028; 0.021)0.045 (−0.022; 0.113)
    Combined P8.4 × 10−50.3260.2720.7610.190
rs112022220.19
    P0.0030.1310.043/0.2730.669/0.9100.014/0.221
    β0.0310.0080.014/0.0070.009/−0.0020.109/0.050
    SE0.0100.0050.007/0.0060.021/0.0210.044/0.040
    Combined β (95% CI)0.028 (0.015; 0.041)0.007 (−0.002; 0.016)0.007 (−0.002; 0.016)−0.005 (−0.030; 0.020)0.030 (−0.041; 0.101)
    Combined P3.4 × 10−50.1180.1030.6850.413
rs107885280.13
    P0.0010.4100.094/0.5430.682/0.8810.018/0.290
    β0.0380.0050.013/0.0040.010/−0.0040.119/0.049
    SE0.0120.0060.008/0.0070.024/0.0240.050/0.046
    Combined β (95% CI)0.032 (0.017; 0.047)0.007 (−0.003; 0.017)0.005 (−0.005; 0.015)−0.005 (−0.034; 0.024)0.037 (−0.045; 0.119)
    Combined P3.0 × 10−50.1800.3560.7260.376
rs79228460.27
    P0.1180.9770.247/0.6440.438/0.6790.833/0.424
    β0.0140.00010.007/0.0030.014/0.0070.008/−0.028
    SE0.0090.0050.006/0.0060.018/0.0180.039/0.035
    Combined β (95% CI)0.013 (0.001; 0.025)0.004 (−0.005; 0.012)0.005 (−0.004; 0.013)0.026 (0.003; 0.048)−0.005 (−0.068; 0.058)
    Combined P0.0310.3780.2890.0250.879
  • Data represent subjects without type 2 diabetes (n = 798). Parameters were ln transformed before analyses. P values were adjusted for age and sex for all variables; for the variables fasting plasma glucose, fasting plasma insulin, and 2-h plasma glucose, the first P value was calculated after adjusting for age and sex and the second P value after adjusting for age, sex, and BMI. β indicates effect directions of the major allele in additive mode of inheritance. Combined β and P values represent the estimated combined effects in the two cohorts (Leipzig and Sorbs) assessed by meta-analysis. Combined P values for the variables fasting plasma glucose, fasting plasma insulin, and 2-h plasma glucose were calculated after adjusting for age, sex, and BMI; for variables BMI and WHR adjustments were made for age and sex.