TABLE 1

Basic characteristics of study participants

Belfast, U.K.Manchester, U.K.Brisbane, AustraliaNewcastle, AustraliaBangkok, Thailand
Pregnant women (n)*1,2841,0859594831,706
Gestational age at which OGTT was performed (weeks)29.0 ± 1.228.4 ± 1.028.1 ± 1.228.1 ± 1.528.1 ± 1.7
Age at OGTT (years)29.8 ± 5.530.8 ± 5.629.2 ± 5.329.5 ± 5.527.9 ± 5.5
BMI at OGTT (kg/m2)28.4 ± 4.929.0 ± 5.529.0 ± 5.729.7 ± 6.025.6 ± 3.6
Mean arterial pressure at OGTT (mmHg)83.6 ± 7.983.5 ± 8.083.8 ± 7.782.9 ± 8.180.1 ± 7.8
FPG (mmol/l)4.63 ± 0.374.61 ± 0.404.43 ± 0.354.54 ± 0.414.44 ± 0.37
1-h plasma glucose (mmol/l)7.50 ± 1.707.46 ± 1.807.40 ± 1.517.33 ± 1.668.27 ± 1.75
2-h plasma glucose (mmol/l)6.08 ± 1.235.99 ± 1.356.25 ± 1.206.21 ± 1.336.66 ± 1.40
Offspring birth weight in g3,526 ± 4893,511 ± 4983,552 ± 4663,585 ± 4663,142 ± 399
Gestational age at delivery (weeks)40.1 ± 1.140.0 ± 1.340.0 ± 1.240.1 ± 1.239.4 ± 1.2
Male offspring (%)50.652.151.151.248.7
Maternal smoking during pregnancy (%)23.719.213.215.50.6
Primiparous births (%)50.247.855.846.153.3
  • Data are means ± SD unless otherwise indicated.

  • *Number of women with fasting glucose, GCK rs1779984 genotype, age, BMI, and mean arterial pressure available. The numbers with TCF7L2 rs7903146 genotype were very similar.

  • †Excluding births before 37 completed weeks of gestation and pregnancies in which caregivers were not blinded to maternal glucose levels. FPG, fasting plasma glucose.