TABLE 4

Association between GCK or TCF7L2 genotype and high* maternal glucose levels

Ancestry and genotypeNo. of women with high/normal glucose (% high)Per T-allele OR (95% CI) for high glucoseP
GCK rs1799884
    European1.29 (1.09–1.50)0.001
        CC388/2,575 (15.1)
        CT194/1,114 (17.4)
        TT32/122 (26.2)
    Thai1.42 (1.06–1.77)0.007
        CC288/1,375 (20.9)
        CT91/311 (29.3)
        TT5/20 (25.0)
TCF7L2 rs7903146
    European1.15 (1.00–1.31)0.04
        CC293/1,884 (15.6)
        CT246/1,557 (15.8)
        TT75/370 (20.3)
    Thai1.39 (0.88–1.90)0.08
        CC338/1,549 (21.8)
        CT/TT46/157 (29.3)
  • *Defined as fasting glucose ≥5.1 mmol/l or 1-h glucose ≥10.0 mmol/l or 2-h glucose ≥8.5 mmol/l.

  • †ORs and P values are from logistic regression of high glucose status (1 or 0) against genotype (coded 0, 1, or 2 T-alleles), with field center (European ancestry only), age, BMI, and mean arterial pressure as covariates. Age, BMI, and mean arterial pressure were measured at a median of 28–29 weeks' gestation, depending on the field center.

  • ‡Categories are combined because of the small number of TT homozygotes (n = 3).