TABLE 2

Characteristics of Medalist study participants by DCCT categories of residual insulin production

Undetectable <0.03 nmol/lMinimal 0.03–0.2 nmol/lSustained ≥0.2 nmol/lP*
N (%)33.0 (126)64.4 (246)2.6 (10)
Male42.6 (55)50.2 (123)52.9 (7)0.4
A1C (%)7.5 ± 1.07.1 ± 1.17.32 ± 0.70.005
Age (years)67.5 ± 8.167.0 ± 7.271.7 ± 8.30.09
Age at diagnosis (years)10.9 ± 6.810.9 ± 6.116.2 ± 8.60.02
Duration (years)56.4 ± 6.056.1 ± 5.755.5 ± 4.10.7
BMI (kg/m2)26.7 ± 2.826.0 ± 4.323.8 ± 3.60.5
Insulin dose (u/kg)0.47 ± 0.20.5 ± 0.20.4 ± 0.20.5
Cholesterol (mmol/l)4.2 ± 0.94.2 ± 0.94.2 ± 1.10.8
Calculated HDL (mmol/l)1.6 ± 0.91.6 ± 0.51.7 ± 0.60.7
LDL (mmol/l)2.2 ± 0.62.2 ± 0.62.2 ± 0.90.5
Triglycerides (mmol/l)0.92 ± 0.50.89 ± 0.510.98 ± 0.650.9
Family history of diabetes
    Any diabetes27.8 (35)31.7 (78)20.0 (2)0.6
    Type 1 diabetes11.9 (15)14.2 (35)10.0 (1)0.8
DR333.6 (39)43.8 (84)57.1 (4)0.03
DR442.2 (49)57.7 (112)42.9 (3)0.03
DR3/444.8 (52)36.6 (71)14.3 (1)0.14
DR3 or DR495.7 (116)92.2 (177)100.0 (7)0.4
IA2 or GAD32.8 (40)27.2 (64)40.0 (4)0.7
IA216.3 (20)13.9 (33)00.3
GAD21.1 (26)16.0 (38)36.4 (4)0.1
Proliferative DR53.9 (56)52.7 (97)36.4 (4)0.5
Microalbuminuria (ACR <7.91)15.1 (18)10.8 (19)23.1 (3)0.3
Neuropathy (MNSI >2)60.4 (67)60.7 (99)60.0 (6)0.9
Cardiovascular disease46.4 (52)50.0 (96)50.0 (5)0.8
MMTT response0 (0/3)14.2 (3/21)57.1 (4/7)<0.0001
  • Data are means ± SD or % (n).

  • †Percentages reflect calculations done on data available.

  • *P values resulted from ANOVA.