TABLE 1

Metabolic parameters in B6 vs. 129 mice at different ages and dietary conditions

Chow diet (21% fat)Low-fat diet (14% fat)High-fat diet (55% fat)
6 weeks old6 months old
B6129B6129B6129B6129
Body weight (g)21.9 ± 0.623.5 ± 0.545.5 ± 1.030.4 ± 1.241.5 ± 1.430.9 ± 1.246.4 ± 1.139.2 ± 1.5
Epididymal fat mass (g)0.09 ± 0.010.21 ± 0.021.67 ± 0.142.14 ± 0.301.62 ± 0.170.58 ± 0.113.39 ± 0.333.92 ± 0.14
Blood glucose– random fed (mg/dl)155.5 ± 3.1129.3 ± 2.9168.2 ± 12.3106.6 ± 3.5148.5 ± 7.4102.5 ± 3.4153.3 ± 6.7105.5 ± 3.7
Insulin (ng/ml)2.26 ± 0.483.12 ± 0.5892.14 ± 25.713.96 ± 2.0424.78 ± 12.511.29 ± 0.3232.73 ± 12.463.58 ± 0.41
Leptin (ng/ml)7.14 ± 0.709.00 ± 0.9076.18 ± 3.8216.67 ± 4.572.50 ± 8.064.97 ± 0.7782.38 ± 7.4146.81 ± 6.02
  • Values are expressed as mean ± SE of 8 animals per group.