HLA class I allele frequencies in 3,506 chromosomes from 1,753 type 1 diabetic probands and 1,585 affected family-based control chromosomes
| Allele | Type 1 diabetes (n) | AFBAC (n) | P |
|---|---|---|---|
| A*0101 | 17.7 (621) | 16.1 (256) | 0.214 |
| A*0102 | 0.1 (4) | 0 (0) | 0.179 |
| A*0103 | 0 (0) | 0.1 (2) | 0.035 |
| A*0201 | 30.6 (1,074) | 27.6 (438) | 0.069 |
| A*0202 | 0.2 (8) | 0 (0) | 0.057 |
| A*0205 | 2.1 (73) | 1.2 (19) | 0.030 |
| A*0206 | 0.3 (9) | 0.2 (3) | 0.646 |
| A*0211 | 0 (1) | 0 (0) | 0.501 |
| A*0220 | 0 (0) | 0.1 (1) | 0.137 |
| A*0234 | 0 (0) | 0.1 (1) | 0.137 |
| A*0235 | 0 (0) | 0.1 (1) | 0.137 |
| A*0301 | 11.9 (417) | 13.1 (207) | 0.271 |
| A*0302 | 0.5 (16) | 0.3 (4) | 0.282 |
| A*0305 | 0 (0) | 0.1 (1) | 0.137 |
| A*1101 | 3.4 (119) | 6.9 (109) | 5.E-08 |
| A*1105 | 0 (0) | 0.1 (1) | 0.137 |
| A*2301 | 1.2 (43) | 1.8 (29) | 0.094 |
| A*2401 | 0 (0) | 0.1 (1) | 0.137 |
| A*2402 | 11.3 (396) | 7.8 (123) | 2.E-04 |
| A*2403 | 0.3 (10) | 0.1 (1) | 0.114 |
| A*2501 | 2.3 (80) | 2.6 (42) | 0.432 |
| A*2601 | 2.6 (90) | 2.8 (44) | 0.671 |
| A*2607 | 0 (0) | 0.1 (1) | 0.137 |
| A*2608 | 0.1 (2) | 0 (0) | 0.342 |
| A*2901 | 0.3 (12) | 0.4 (6) | 0.840 |
| A*2902 | 2.3 (80) | 3.4 (54) | 0.022 |
| A*3001 | 0.7 (25) | 1.1 (17) | 0.191 |
| A*3002 | 3.3 (117) | 1.7 (27) | 0.001 |
| A*3004 | 0.1 (2) | 0.1 (1) | 0.934 |
| A*3010 | 0 (1) | 0 (0) | 0.501 |
| A*3101 | 2.1 (74) | 1.9 (30) | 0.614 |
| A*3201 | 2.1 (73) | 4.2 (67) | 2.E-05 |
| A*3204 | 0 (0) | 0.1 (1) | 0.137 |
| A*3301 | 0.8 (27) | 1 (16) | 0.390 |
| A*3303 | 0.4 (14) | 0.3 (5) | 0.650 |
| A*3402 | 0.2 (6) | 0.1 (1) | 0.336 |
| A*3601 | 0 (1) | 0.1 (2) | 0.184 |
| A*6601 | 0.1 (3) | 0.6 (10) | 4.E-04 |
| A*6602 | 0.1 (2) | 0 (0) | 0.342 |
| A*6801 | 2.6 (91) | 2.7 (43) | 0.811 |
| A*6802 | 0.4 (14) | 1.3 (20) | 5.E-04 |
| A*6901 | 0 (0) | 0.1 (1) | 0.137 |
| A*7401 | 0 (0) | 0.1 (1) | 0.137 |
| A*8001 | 0 (1) | 0 (0) | 0.501 |
| B*0702 | 7 (244) | 14.7 (233) | 7.E-17 |
| B*0704 | 0 (0) | 0.1 (1) | 0.137 |
| B*0705 | 0.7 (26) | 0.3 (4) | 0.035 |
| B*0707 | 0 (0) | 0.1 (1) | 0.137 |
| B*0801 | 21 (735) | 10.9 (173) | 4.E-15 |
| B*0809 | 0 (0) | 0.1 (1) | 0.137 |
| B*1302 | 1.8 (64) | 2 (31) | 0.752 |
| B*1401 | 0.2 (8) | 0.6 (9) | 0.052 |
| B*1402 | 1.7 (60) | 2.6 (41) | 0.040 |
| B*1501 | 12.3 (432) | 4.5 (71) | 2.E-16 |
| B*1502 | 0.1 (2) | 0 (0) | 0.342 |
| B*1503 | 0.1 (5) | 0.1 (1) | 0.444 |
| B*1507 | 0.1 (3) | 0 (0) | 0.244 |
| B*1508 | 0 (1) | 0 (0) | 0.501 |
| B*1509 | 0.1 (2) | 0.1 (1) | 0.934 |
| B*1510 | 0.1 (4) | 0 (0) | 0.179 |
| B*1515 | 0 (1) | 0 (0) | 0.501 |
| B*1516 | 0 (1) | 0.1 (1) | 0.564 |
| B*1517 | 0.4 (15) | 0.3 (4) | 0.343 |
| B*1518 | 0.2 (6) | 0.3 (5) | 0.305 |
| B*1524 | 0.1 (3) | 0 (0) | 0.244 |
| B*1525 | 0 (0) | 0.1 (1) | 0.137 |
| B*1537 | 0 (1) | 0 (0) | 0.501 |
| B*1571 | 0 (0) | 0.1 (1) | 0.137 |
| B*1573 | 0 (0) | 0.1 (1) | 0.137 |
| B*1801 | 10.2 (357) | 6.3 (100) | 2.E-05 |
| B*1812 | 0 (1) | 0 (0) | 0.501 |
| B*2701 | 0 (0) | 0.1 (1) | 0.137 |
| B*2702 | 0.3 (9) | 0.4 (6) | 0.458 |
| B*2703 | 3.2 (113) | 3.1 (49) | 0.807 |
| B*2707 | 0 (1) | 0.1 (2) | 0.184 |
| B*3501 | 3.6 (126) | 6.3 (100) | 2.E-05 |
| B*3502 | 0.3 (12) | 1.5 (23) | 1.E-05 |
| B*3503 | 1.6 (56) | 1.5 (23) | 0.698 |
| B*3508 | 0.3 (12) | 0.5 (8) | 0.392 |
| B*3512 | 0 (0) | 0.1 (1) | 0.137 |
| B*3701 | 0.7 (23) | 1 (16) | 0.182 |
| B*3801 | 1.8 (63) | 2.5 (40) | 0.091 |
| B*3901 | 1.2 (42) | 1.2 (19) | 0.998 |
| B*3906 | 3.2 (112) | 0.4 (7) | 3.E-09 |
| B*4001 | 5.6 (198) | 4.4 (69) | 0.062 |
| B*4002 | 0.6 (20) | 1.6 (25) | 4.E-04 |
| B*4006 | 0.1 (3) | 0.2 (3) | 0.318 |
| B*4009 | 0 (1) | 0 (0) | 0.501 |
| B*4014 | 0 (0) | 0.1 (2) | 0.035 |
| B*4101 | 1 (34) | 0.3 (4) | 0.006 |
| B*4102 | 0.1 (2) | 0.4 (6) | 0.007 |
| B*4201 | 0 (1) | 0 (0) | 0.501 |
| B*4202 | 0 (0) | 0.1 (1) | 0.137 |
| B*4402 | 6 (210) | 9 (143) | 1.E-04 |
| B*4403 | 2 (69) | 5.7 (91) | 2.E-12 |
| B*4404 | 0 (0) | 0.1 (1) | 0.137 |
| B*4405 | 0.2 (7) | 0.1 (1) | 0.255 |
| B*4501 | 0.5 (17) | 0.4 (7) | 0.835 |
| B*4701 | 0.3 (10) | 0.4 (6) | 0.582 |
| B*4702 | 0 (1) | 0 (0) | 0.501 |
| B*4801 | 0.1 (2) | 0.1 (1) | 0.934 |
| B*4901 | 2.2 (77) | 1.1 (17) | 0.006 |
| B*5001 | 2.1 (75) | 1.2 (19) | 0.022 |
| B*5002 | 0.1 (2) | 0.1 (1) | 0.934 |
| B*5101 | 3 (104) | 4.2 (67) | 0.023 |
| B*5102 | 0 (0) | 0.1 (1) | 0.137 |
| B*5105 | 0 (0) | 0.1 (1) | 0.137 |
| B*5107 | 0 (1) | 0.1 (1) | 0.564 |
| B*5108 | 0.1 (4) | 0.1 (1) | 0.591 |
| B*5201 | 0.3 (12) | 1.1 (18) | 0.001 |
| B*5301 | 0.1 (5) | 0.5 (8) | 0.018 |
| B*5501 | 0.9 (30) | 1.6 (26) | 0.013 |
| B*5601 | 0.6 (20) | 0.6 (10) | 0.795 |
| B*5701 | 0.5 (19) | 3.5 (56) | 4.E-16 |
| B*5703 | 0 (1) | 0.3 (5) | 0.006 |
| B*5801 | 0.9 (31) | 1.1 (18) | 0.397 |
| B*7301 | 0.3 (9) | 0.1 (1) | 0.149 |
| B*8101 | 0 (1) | 0 (0) | 0.501 |
| C*0102 | 2 (69) | 3 (48) | 0.021 |
| C*0202 | 3.9 (136) | 4.4 (69) | 0.435 |
| C*0206 | 0 (1) | 0.1 (1) | 0.564 |
| C*0302 | 0.3 (12) | 0.4 (7) | 0.591 |
| C*0303 | 5.5 (194) | 3.9 (62) | 0.017 |
| C*0304 | 13.5 (475) | 6.6 (105) | 1.E-11 |
| C*0305 | 0.1 (3) | 0 (0) | 0.244 |
| C*0314 | 0 (1) | 0 (0) | 0.501 |
| C*0401 | 6 (212) | 11.6 (184) | 4.E-11 |
| C*0403 | 0 (0) | 0.1 (1) | 0.137 |
| C*0501 | 11.3 (397) | 9.5 (150) | 0.061 |
| C*0602 | 5.9 (208) | 8.4 (133) | 0.002 |
| C*0606 | 0 (1) | 0 (0) | 0.501 |
| C*0701 | 25.7 (900) | 15 (238) | 1.E-13 |
| C*0702 | 10.8 (378) | 15.6 (247) | 6.E-06 |
| C*0704 | 1 (34) | 1.9 (30) | 0.007 |
| C*0801 | 0.1 (5) | 0.1 (2) | 0.884 |
| C*0802 | 1.9 (66) | 3.2 (50) | 0.005 |
| C*1202 | 0.3 (12) | 1.1 (17) | 0.001 |
| C*1203 | 5.7 (200) | 6.4 (102) | 0.322 |
| C*1402 | 0.7 (25) | 1.2 (19) | 0.084 |
| C*1502 | 1.4 (50) | 2 (32) | 0.123 |
| C*1504 | 0.2 (8) | 0.1 (2) | 0.447 |
| C*1505 | 0.8 (27) | 0.3 (5) | 0.058 |
| C*1601 | 1.2 (43) | 3.8 (60) | 3.E-09 |
| C*1602 | 0.5 (17) | 0.2 (3) | 0.119 |
| C*1604 | 0.1 (4) | 0.4 (6) | 0.049 |
| C*1701 | 0.8 (27) | 0.7 (11) | 0.771 |
| C*1801 | 0 (1) | 0.1 (1) | 0.564 |
P values lower than 0.1 are shown in boldface type.