TABLE 2

Associations of the individual obesity susceptibility SNPs and the GPS-12 and GPS-17 with anthropometric traits in children and adolescents of the EYHS (n = 2,042)

SNP nearest geneBMISum of skinfoldsWaist circumferenceHeight
Effect size (SD/allele)SEPEffect size (SD/allele)SEPEffect size (SD/allele)SEPEffect size (SD/allele)SEP
rs2815752NEGR10.0810.038.9 × 10−30.0520.030.060.0620.024.8 × 10−30.0310.030.32
rs10913469SEC16B0.1360.044.2 × 10−40.1260.032.5 × 10−40.0750.036.8 × 10−3−0.0090.040.82
rs2605100*LYPLAL10.0120.030.730.0600.033.9 × 10−20.0600.021.0 × 10−2−0.0270.030.42
rs6548238TMEM180.1480.041.9 × 10−40.1500.042.5 × 10−50.0680.031.6 × 10−20.0850.043.8 × 10−2
rs7647305ETV50.0480.040.210.0280.030.420.0300.030.270.0340.040.39
rs10938397GNPDA20.0510.030.080.0610.032.5 × 10−20.0410.020.06−0.0040.030.89
rs987237*TFAP2B0.0690.040.060.0420.030.210.0560.033.5 × 10−2−0.0250.040.50
rs545854*MSRA−0.0800.040.070.0010.040.99−0.0500.030.10−0.0330.040.47
rs1488830BDNF0.0370.040.350.0280.030.410.0030.030.910.0260.040.52
rs925946BDNF0.0570.030.080.0650.032.7 × 10−20.0340.020.140.0520.030.12
rs10838738MTCH2−0.0170.030.61−0.0120.030.670.0010.020.97−0.0420.030.21
rs7138803BCDIN3D0.0450.030.130.0290.030.280.0230.020.290.0780.031.3 × 10−2
rs10146997*NRXN30.0220.040.560.0290.030.380.0180.030.510.0390.040.31
rs8055138SH2B10.0120.030.680.0310.030.260.0040.020.870.0040.030.91
rs1121980FTO0.0200.030.470.0330.030.220.0040.020.850.0090.030.77
rs17782313MC4R0.0130.040.720.0150.030.65−0.0060.030.830.0040.040.93
rs11084753KCTD150.0200.030.540.0230.030.410.0090.020.690.0390.030.24
GPS-120.0440.017.1 × 10−60.0430.017.2 × 10−70.0250.013.4 × 10−40.0230.012.4 × 10−2
GPS-170.0340.013.6 × 10−50.0390.011.7 × 10−70.0220.011.7 × 10−40.0120.010.15
  • Results were obtained using multiple linear regression analysis assuming an additive effect while adjusting for sex, age, age-group, country, and maturity. The sum of skinfolds and waist circumference were additionally adjusted for height.

  • *Located in or near loci identified in GWA studies for waist circumference; all other SNPs were identified in GWA studies for BMI.