TABLE 3

Linear regression analysis of variables associated with changes in serum omentin-1 levels (before and after metformin treatment), Δomentin-1, in PCOS subjects (n = 21)

VariableSimpleMultiple
rPβP
BMI (kg/m2)−0.4000.072
WHR−0.4450.043−0.1890.338
Glucose (mmol/l)−0.4710.031−0.0380.906
Insulin (pmol/l)−0.0140.953
HOMA-IR−0.4610.035−0.1490.611
Cholesterol (mmol/l)0.1000.667
Triglycerides (mmol/l)0.3900.080
Testosterone (nmol/l)−0.1260.586
Androstenedione (nmol/l)0.1390.548
DHEA-S (μmol/l)−0.2320.311
SHBG (nmol/l)0.1310.570
FAI−0.2000.385
SBP (mmHg)−0.2220.333
DBP (mmHg)0.0320.889
IMT (mm)−0.0320.892
hs-CRP (mg/l)−0.665<0.010−0.5260.036
  • Spearman rank correlation was used for calculation of associations between variables. If individual bivariate correlations achieved statistical significance, multiple regression analysis with omentin-1 as dependent variable was performed to test the joint effect of these parameters on omentin-1. Multiple regression analysis contained WHR, glucose, HOMA-IR, and hs-CRP. DHEA-S, dehydroepiandrosterone-sulfate; SHBG, sex hormone–binding globulin; FAI, free androgen index; SBP, systolic blood pressure; DBP, diastolic blood pressure.