TABLE 1

Metabolic parameters of mice with and without hepatic leptin signaling

Metabolic parameter
Body weight (g)Fastinga glucose (mM)Random-fedb glucose (mM)Fastinga insulin (ng/ml)
6 weeksLeprflox/flox Albcre tg25.7 ± 0.5 (22)9.7 ± 0.3 (22)8.3 ± 0.4 (7)1.17 ± 0.13 (5)
Leprflox/flox Albcre tg+25.6 ± 0.5 (24)9.3 ± 0.3 (24)7.6 ± 0.3 (8)1.09 ± 0.11 (5)
C57BL/620.5 ± 0.5 (8)11.1 ± 0.3 (16)9.0 ± 0.4 (8)0.86 ± 0.06 (8)
db/db30.0 ± 0.7 (8)*15.1 ± 1.8 (8)*28.1 ± 1.6 (8)*7.89 ± 0.91 (8)*
Leprflox/flox Albcre tg20.5 ± 0.3 (18)8.3 ± 0.3 (18)7.3 ± 0.3 (8)0.53 ± 0.15 (6)
Leprflox/flox Albcre tg+19.7 ± 0.3 (17)8.5 ± 0.3 (16)7.2 ± 0.2 (5)0.34 ± 0.05 (3)
C57BL/616.0 ± 0.4 (8)8.0 ± 0.3 (8)8.1 ± 0.4 (8)0.53 ± 0.09 (4)
db/db31.6 ± 0.5 (8)*22.1 ± 1.6 (8)*28.9 ± 0.5 (8)*10.18 ± 1.38 (7)*
12 weeksLeprflox/flox Albcre tg34.0 ± 0.9 (29)10.1 ± 0.3 (29)8.3 ± 0.4 (6)1.38 ± 0.30 (6)
Leprflox/flox Albcre tg+32.6 ± 0.9 (35)9.9 ± 0.3 (35)8.0 ± 0.3 (7)1.32 ± 0.29 (7)
C57BL/628.8 ± 1.0 (14)11.1 ± 0.4 (14)9.0 ± 0.2 (8)2.61 ± 0.76 (8)
db/db50.5 ± 0.9 (8)*28.0 ± 1.0 (8)*28.1 ± 1.1 (8)*11.2 ± 2.2 (8)*
Leprflox/flox Albcre tg22.2 ± 0.9 (27)7.9 ± 0.3 (27)8.0 ± 0.3 (5)0.54 ± 0.10 (5)
Leprflox/flox Albcre tg+23.1 ± 0.5 (22)7.7 ± 0.2 (22)8.0 ± 0.2 (5)0.48 ± 0.17 (5)
C57BL/618.7 ± 0.6 (8)7.2 ± 0.4 (8)7.0 ± 0.1 (8)0.49 ± 0.06 (8)
db/db51.7 ± 0.6 (8)*28.1 ± 2.2 (8)*24.8 ± 2.4 (8)*7.46 ± 0.76 (8)*
16 weeksLeprflox/flox Albcre tg41.6 ± 1.1 (24)10.9 ± 0.5 (24)7.8 ± 0.4 (5)2.00 ± 0.41 (18)
Leprflox/flox Albcre tg+39.1 ± 1.1 (25)10.6 ± 0.3 (26)8.6 ± 0.5 (7)1.70 ± 0.25 (23)
C57BL/631.7 ± 1.0 (14)9.7 ± 0.3 (14)8.2 ± 0.5 (8)2.32 ± 0.77 (8)
db/db56.7 ± 0.9 (8)*25.6 ± 2.8 (8)*25.1 ± 1.8 (8)*12.0 ± 2.10 (8)*
Leprflox/flox Albcre tg26.9 ± 1.2 (12)7.5 ± 0.4 (12)7.5 ± 0.3 (5)0.82 ± 0.20 (4)
Leprflox/flox Albcre tg+25.4 ± 1.0 (8)7.2 ± 0.2 (8)7.3 ± 0.3 (5)0.41 ± 0.01 (4)*
C57BL/620.4 ± 0.7 (8)8.4 ± 0.5 (8)7.5 ± 0.2 (8)0.37 ± 0.06 (8)
db/db57.9 ± 0.6 (8)*21.7 ± 2.5 (8)*21.0 ± 2.8 (8)*9.67 ± 1.42 (6)*
  • aMice were fasted for 4 h during the light cycle.

  • bSamples were collected between 11:00 p.m.–1:00 a.m.

  • *P ≤ 0.05 vs. control (Leprflox/flox Albcre tg or C57BL/6).