TABLE 2

Peak clinical and systemic inflammatory responses during endotoxemia

Pre-LPSPost-LPSTime of peak (h)
Plasma IL-6 (ng/ml)3.2 ± 17.11,607 ± 650*2
Plasma TNF (ng/ml)3.0 ± 1.1507 ± 251*2
Heart rate (bpm)83 ± 11103 ± 144
Temperature (°C)36.5 ± 0.537.7 ± 1.0†4
White blood cell count (mg/μl)6.5 ± 0.912.9 ± 4.1†12
Plasma hsCRP0.49 ± 0.2142.4 ± 8.4†24
  • Clinical parameters and plasma levels of cytokines are presented as means ± SD.

  • *P < 0.0001;

  • P < 0.005.