Associations with HbA1C of 10 independent loci conditioned on levels of fasting or 2-h glucose
SNP | Nearest locus | Effect/Other | Fasting glucose | 2-h glucose | |||||
---|---|---|---|---|---|---|---|---|---|
HbA1C (%) adjusted for sex, age | HbA1C (%) adjusted for glucose, sex, age | Fasting glucose (mmol/l) adjusted for sex, age | HbA1C (%) adjusted for sex. age | HbA1C (%) adjusted for 2 h-glucose, sex, age | 2-h glucose (mmol/l) adjusted for sex, age | ||||
rs2779116 | SPTA1 | T/C | β (SE) | 0.019 (0.004) | 0.017 (0.004) | −0.001 (0.005) | 0.026 (0.008) | 0.029 (0.008) | 0.029 (0.037) |
P | 2.4 × 10−6 | 1.7 × 10−6 | 0.900 | 9.6 × 10−4 | 2.9 × 10−4 | 0.432 | |||
N | 20,700 | 21,359 | 21,505 | 6,394 | 6,347 | 6,347 | |||
rs552976 | G6PC2 /ABCB11 | G/A | β (SE) | 0.028 (0.004) | 0.013 (0.003) | 0.060 (0.005) | 0.029 (0.007) | 0.027 (0.007) | −0.021 (0.034) |
P | 4.5 × 10−15 | 2.0 × 10−5 | 6.3 × 10−36 | 6.1 × 10−5 | 1.4 × 10−4 | 0.538 | |||
N | 23,496 | 23,496 | 23,642 | 6,393 | 6,346 | 6,346 | |||
rs1800562 | HFE | G/A | β (SE) | 0.054 (0.007) | 0.048 (0.006) | −0.008 (0.010) | 0.095 (0.016) | 0.096 (0.016) | 0.086 (0.073) |
P | 3.1 × 10−13 | 2.5 × 10−14 | 0.419 | 1.1 × 10−9 | 1.1 × 10−9 | 0.239 | |||
N | 23,503 | 23,503 | 23,649 | 6,389 | 6,342 | 6,342 | |||
rs1799884 | GCK | T/C | β (SE) | 0.030 (0.005) | 0.018 (0.004) | 0.053 (0.0063) | 0.037 (0.010) | 0.039 (0.010) | 0.111 (0.046) |
P | 5.6 × 10−11 | 7.3 × 10−6 | 4.7 × 10−17 | 1.3 × 10−4 | 6.2 × 10−5 | 0.0143 | |||
N | 23,497 | 23,497 | 23,643 | 6,394 | 6,347 | 6,347 | |||
rs4737009 | ANK1 | A/G | β (SE) | 0.023 (0.004) | 0.017 (0.004) | 0.010 (0.006) | 0.023 (0.008) | 0.025 (0.008) | −0.049 (0.038) |
P | 3.2 × 10−8 | 2.7 × 10−6 | 0.072 | 4.4 × 10−3 | 2.3 × 10−3 | 0.197 | |||
N | 21,355 | 21,355 | 21,501 | 6,390 | 6,343 | 6,343 | |||
rs16926246 | HK1 | C/T | β (SE) | 0.073 (0.007) | 0.069 (0.006) | −0.013 (0.009) | 0.010 (0.017) | 0.097 (0.017) | 0.012 (0.092) |
P | 4.8 × 10−26 | 6.4 × 10−30 | 0.178 | 1.6 × 10−9 | 1.3 × 10−8 | 0.899 | |||
N | 22,404 | 22,404 | 22,550 | 5,301 | 5,254 | 5,254 | |||
rs1387153 | MTNR1B | T/C | β (SE) | 0.027 (0.004) | 0.013 (0.004) | 0.056 (0.006) | 0.035 (0.008) | 0.032 (0.009) | 0.036 (0.040) |
P | 1.9 × 10−11 | 2.2 × 10−4 | 1.8 × 10−23 | 3.1 × 10−5 | 1.5 × 10−4 | 0.362 | |||
N | 20,162 | 20,162 | 20,308 | 6,394 | 6,347 | 6,347 | |||
rs7998202 | ATP11A/TUBGCP3 | G/A | β (SE) | 0.027 (0.006) | 0.023 (0.005) | 0.013 (0.008) | 0.041 (0.012) | 0.035 (0.012) | −0.035 (0.054) |
P | 3.4 × 10−6 | 1.3 × 10−5 | 0.108 | 4.0 × 10−4 | 2.6 × 10−3 | 0.512 | |||
N | 21,359 | 21,359 | 21,505 | 6,394 | 6,347 | 6,347 | |||
rs1046896 | FN3K | T/C | β (SE) | 0.030 (0.004) | 0.026 (0.003) | 0.005 (0.005) | 0.045 (0.008) | 0.043 (0.008) | −0.011 (0.036) |
P | 2.0 × 10−16 | 1.0 × 10−15 | 0.343 | 3.0 × 10−9 | 2.0 × 10−8 | 0.753 | |||
N | 23,496 | 23,496 | 23,642 | 6,393 | 6,346 | 6,346 | |||
rs855791 | TMPRSS6 | A/G | β (SE) | 0.020 (0.004) | 0.019 (0.003) | −0.006 (0.005) | 0.024 (0.008) | 0.022 (0.008) | 0.009 (0.036) |
P | 6.7 × 10−8 | 8.3 × 10−9 | 0.223 | 1.7 × 10−3 | 6.1 × 10−3 | 0.815 | |||
N | 23,508 | 23,508 | 23,654 | 6,394 | 6,347 | 6,347 |
β (SE) is the per-effect allele increase in HbA1C (%) as in Table 2. For analyses conditional on fasting glucose, data were available for up to 23,654 samples from 15 cohorts (ARIC, BLSA, CROATIA, Fenland, FHS, DESIR, GENOMEUTWIN, Lolipop, NTR, ORCADES, SardiNIA, KORA F4, DGI, Sorbs and Health2000). For analyses conditional on 2-h glucose, data were available for only a smaller set of six cohorts totaling up to 6,394 samples (BLSA, Fenland, FHS, KORA F4, DGI and Sorbs). The SNP association with HbA1C after adjusting for fasting glucose is attenuated most at the G6PC2/ABCB11, GCK and MTNR1B loci. Associations at ANK1 are given for rs4737009, with the ANK1 SNP showing the strongest association with HbA1C.