TABLE 3

Associations with HbA_1C of 10 independent loci conditioned on levels of fasting or 2-h glucose

SNP	Nearest locus	Effect/Other		Fasting glucose			2-h glucose
SNP	Nearest locus	Effect/Other		HbA_1C (%) adjusted for sex, age	HbA_1C (%) adjusted for glucose, sex, age	Fasting glucose (mmol/l) adjusted for sex, age	HbA_1C (%) adjusted for sex. age	HbA_1C (%) adjusted for 2 h-glucose, sex, age	2-h glucose (mmol/l) adjusted for sex, age
rs2779116	SPTA1	T/C	β (SE)	0.019 (0.004)	0.017 (0.004)	−0.001 (0.005)	0.026 (0.008)	0.029 (0.008)	0.029 (0.037)
			P	2.4 × 10⁻⁶	1.7 × 10⁻⁶	0.900	9.6 × 10⁻⁴	2.9 × 10⁻⁴	0.432
			N	20,700	21,359	21,505	6,394	6,347	6,347
rs552976	G6PC2 /ABCB11	G/A	β (SE)	0.028 (0.004)	0.013 (0.003)	0.060 (0.005)	0.029 (0.007)	0.027 (0.007)	−0.021 (0.034)
			P	4.5 × 10⁻¹⁵	2.0 × 10⁻⁵	6.3 × 10⁻³⁶	6.1 × 10⁻⁵	1.4 × 10⁻⁴	0.538
			N	23,496	23,496	23,642	6,393	6,346	6,346
rs1800562	HFE	G/A	β (SE)	0.054 (0.007)	0.048 (0.006)	−0.008 (0.010)	0.095 (0.016)	0.096 (0.016)	0.086 (0.073)
			P	3.1 × 10⁻¹³	2.5 × 10⁻¹⁴	0.419	1.1 × 10⁻⁹	1.1 × 10⁻⁹	0.239
			N	23,503	23,503	23,649	6,389	6,342	6,342
rs1799884	GCK	T/C	β (SE)	0.030 (0.005)	0.018 (0.004)	0.053 (0.0063)	0.037 (0.010)	0.039 (0.010)	0.111 (0.046)
			P	5.6 × 10⁻¹¹	7.3 × 10⁻⁶	4.7 × 10⁻¹⁷	1.3 × 10⁻⁴	6.2 × 10⁻⁵	0.0143
			N	23,497	23,497	23,643	6,394	6,347	6,347
rs4737009	ANK1	A/G	β (SE)	0.023 (0.004)	0.017 (0.004)	0.010 (0.006)	0.023 (0.008)	0.025 (0.008)	−0.049 (0.038)
			P	3.2 × 10⁻⁸	2.7 × 10⁻⁶	0.072	4.4 × 10⁻³	2.3 × 10⁻³	0.197
			N	21,355	21,355	21,501	6,390	6,343	6,343
rs16926246	HK1	C/T	β (SE)	0.073 (0.007)	0.069 (0.006)	−0.013 (0.009)	0.010 (0.017)	0.097 (0.017)	0.012 (0.092)
			P	4.8 × 10⁻²⁶	6.4 × 10⁻³⁰	0.178	1.6 × 10⁻⁹	1.3 × 10⁻⁸	0.899
			N	22,404	22,404	22,550	5,301	5,254	5,254
rs1387153	MTNR1B	T/C	β (SE)	0.027 (0.004)	0.013 (0.004)	0.056 (0.006)	0.035 (0.008)	0.032 (0.009)	0.036 (0.040)
			P	1.9 × 10⁻¹¹	2.2 × 10⁻⁴	1.8 × 10⁻²³	3.1 × 10⁻⁵	1.5 × 10⁻⁴	0.362
			N	20,162	20,162	20,308	6,394	6,347	6,347
rs7998202	ATP11A/TUBGCP3	G/A	β (SE)	0.027 (0.006)	0.023 (0.005)	0.013 (0.008)	0.041 (0.012)	0.035 (0.012)	−0.035 (0.054)
			P	3.4 × 10⁻⁶	1.3 × 10⁻⁵	0.108	4.0 × 10⁻⁴	2.6 × 10⁻³	0.512
			N	21,359	21,359	21,505	6,394	6,347	6,347
rs1046896	FN3K	T/C	β (SE)	0.030 (0.004)	0.026 (0.003)	0.005 (0.005)	0.045 (0.008)	0.043 (0.008)	−0.011 (0.036)
			P	2.0 × 10⁻¹⁶	1.0 × 10⁻¹⁵	0.343	3.0 × 10⁻⁹	2.0 × 10⁻⁸	0.753
			N	23,496	23,496	23,642	6,393	6,346	6,346
rs855791	TMPRSS6	A/G	β (SE)	0.020 (0.004)	0.019 (0.003)	−0.006 (0.005)	0.024 (0.008)	0.022 (0.008)	0.009 (0.036)
			P	6.7 × 10⁻⁸	8.3 × 10⁻⁹	0.223	1.7 × 10⁻³	6.1 × 10⁻³	0.815
			N	23,508	23,508	23,654	6,394	6,347	6,347

β (SE) is the per-effect allele increase in HbA_1C (%) as in Table 2. For analyses conditional on fasting glucose, data were available for up to 23,654 samples from 15 cohorts (ARIC, BLSA, CROATIA, Fenland, FHS, DESIR, GENOMEUTWIN, Lolipop, NTR, ORCADES, SardiNIA, KORA F4, DGI, Sorbs and Health2000). For analyses conditional on 2-h glucose, data were available for only a smaller set of six cohorts totaling up to 6,394 samples (BLSA, Fenland, FHS, KORA F4, DGI and Sorbs). The SNP association with HbA_1C after adjusting for fasting glucose is attenuated most at the G6PC2/ABCB11, GCK and MTNR1B loci. Associations at ANK1 are given for rs4737009, with the ANK1 SNP showing the strongest association with HbA_1C.