TABLE 1

Cox regression analysis of HLA effects on progression to clinical diabetes in children with diabetes-associated autoantibodies

Follow-up from appearance of first biochemically defined autoantibody*
Multivariate analysis
HLA-A*030.0420.611 (0.380–0.982)
HLA-A*240.1911.422 (0.839–2.411)
HLA-B*390.1591.549 (0.843–2.844)
HLA-DR3/40.0701.482 (0.968–2.269)
Follow-up from appearance of second biochemically defined autoantibody
HLA-A*030.0270.552 (0.326–0.933)
HLA-A*240.5981.176 (0.644–2.146)
HLA-B*390.0142.401 (1.196–4.823)
HLA-DR3/40.8091.063 (0.647–1.746)
  • Data are P values and hazard ratio for diabetes progression (95% CI).

  • *Stratified according to age at appearance of first biochemically defined autoantibody.

  • †Stratified according to age at appearance of second biochemically defined autoantibody. DR3/4, (DR3)-DQA1*05-DQB1*02/DRB1*0401/4-DQB1*0302.