TABLE 1

Body weight, epididymal fat, and plasma measurements in the saline- or GdCl3-treated rats exposed to NC, HF, or HS diets for 2 weeks

NC salineNC GdCl3HF salineHF GdCl3HS salineHS GdCl3
Body wt (g), day 0279 ± 3278 ± 8289 ± 3288 ± 7254 ± 14270 ± 9
Body wt (g), day 21375 ± 12351 ± 9371 ± 3382 ± 7352 ± 14346 ± 9
Food intake (Kcal/day)100 ± 296 ± 3110 ± 3104 ± 395 ± 389 ± 5
Epididymal fat (g)6.2 ± 0.35.4 ± 0.36.6 ± 0.26.3 ± 0.85.2 ± 0.55.3 ± 0.5
Glucose (mg/dl)
    Before clamp88 ± 5NA96 ± 789 ± 592 ± 588 ± 7
    After clamp87 ± 7NA101 ± 597 ± 398 ± 893 ± 4
Insulin (ng/ml)
    Before clamp0.5 ± 0.20.6 ± 0.10.8 ± 0.50.8 ± 0.30.5 ± 0.20.6 ± 0.1
    After clamp4.5 ± 1NA5.5 ± 0.94.0 ± 1.25.1 ± 0.84.5 ± 1.3
Plasma TGs (mg/dl)51.2 ± 0.846.7 ± 6.263.4 ± 5.7*76.2 ± 8.6*91.6 ± 8.0*109.9 ± 9.0*
Plasma FFAs (mM)0.6 ± 0.10.4 ± 0.10.7 ± 0.10.5 ± 0.10.7 ± 0.10.5 ± 0.1
Plasma TNFα (pg/ml)36.1 ± 3.434.2 ± 0.842.8 ± 10.454.6 ± 17.934.0 ± 0.439.8 ± 2.2
Plasma LPS (EU/ml)8.3 ± 0.37.4 ± 0.38.5 ± 1.19.1 ± 1.515.0 ± 1.716.2 ± 4.0
  • Data are means ± SE; n = minimum 5/group except post-clamp SC insulin where n = 3. Values for TGs, FFAs, TNFα, and LPS are from overnight-fasted, preclamp blood samples.

  • *Significantly different from NC saline. FFA, free fatty acids; NA, not applicable.