TABLE 1

Selected genes modulated by cytokine treatment detected by array analysis

ProbeGenBankGene name/functional groupSymbol6 h24 h
IL + IFNTNF + IFNIL + IFNTNF + IFN
Arginine metabolism and NO formation
1368266_atNM_017134arg1Arg10.65 ± 0.060.76 ± 0.160.15 ± 0.030.28 ± 0.18
1370964_atBF283456ASSAss5.93 ± 1.300.75 ± 2.5514.21 ± 4.661.73 ± 1.35
1387667_atL12562iNOS2Nos2375.0 ± 59.78109.3 ± 214.5113.8 ± 16.0357.80 ± 21.89
Glucose metabolism
1386916_atNM_017321Aconitase 1 (Krebs)Aco10.23 ± 0.120.38 ± 0.040.41 ± 0.040.56 ± 0.11
1367589_atNM_024398Aconitase 2, mitochondrial (Krebs)Aco20.45 ± 0.080.53 ± 0.070.61 ± 0.030.57 ± 0.06
1375295_atAI009657Citrate synthase (Krebs)Cs0.73 ± 0.180.60 ± 0.041.42 ± 0.151.31 ± 0.05
1367670_atNM_017005Fumarase/fumarate hydratase 1 (Krebs)Fh10.34 ± 0.030.58 ± 0.040.64 ± 0.030.77 ± 0.04
1370865_atBI277627Isocitrate dehydrogenase 3 (NAD), γ (Krebs)Idh3g0.61 ± 0.030.61 ± 0.090.56 ± 0.050.66 ± 0.02
1388160_a_atAI171793Isocitrate dehydrogenase 3 (NAD+) β (Krebs)Idh3B0.67 ± 0.230.74 ± 0.101.30 ± 0.181.39 ± 0.05
1372790_atBG671530Malate dehydrogenase 1, NAD (soluble) (Krebs)Mdh10.47 ± 0.060.53 ± 0.090.20 ± 0.020.29 ± 0.02
1372790_atBG671530Malate dehydrogenase 1, NAD (soluble) (Krebs)Mdh10.47 ± 0.060.53 ± 0.090.20 ± 0.020.29 ± 0.02
1367653_a_atNM_033235Malate dehydrogenase 1, NAD (soluble) (Krebs)Mdh10.67 ± 0.120.66 ± 0.030.52 ± 0.020.52 ± 0.05
1367653_a_atNM_033235Malate dehydrogenase 1, NAD (soluble) (Krebs)Mdh10.67 ± 0.120.66 ± 0.030.52 ± 0.020.52 ± 0.05
1369927_atNM_031151Malate dehydrogenase 2, NAD (mitochondrial) (Krebs)Mdh20.53 ± 0.160.48 ± 0.050.86 ± 0.030.79 ± 0.09
1390020_atBI277513α-Ketoglutarate dehydrogenase (Krebs)αkdgh0.69 ± 0.140.75 ± 0.090.44 ± 0.010.55 ± 0.06
1380813_atAA891239Succinate dehydrogenase complex (Krebs)Sdhb_predicted0.97 ± 0.231.00 ± 0.080.66 ± 0.100.89 ± 0.09
1372123_atAI172320Succinate dehydrogenase complex (Krebs)Sdhb_predicted0.84 ± 0.250.59 ± 0.111.43 ± 0.051.32 ± 0.07
1373017_atAI237518Succinyl-CoA synthetase, β-subunit (Krebs)Suclg20.84 ± 0.240.84 ± 0.060.65 ± 0.080.89 ± 0.02
1367617_atNM_012495Aldolase A (glycolysis)Aldoa0.77 ± 0.080.66 ± 0.011.35 ± 0.131.27 ± 0.04
1387312_a_atNM_012565Glucokinase (glycolysis)Gck0.20 ± 0.070.32 ± 0.140.22 ± 0.050.24 ± 0.10
1383519_atBI294137Hexokinase 2 (glycolysis)Hk24.99 ± 2.6217.22 ± 5.4416.77 ± 8.1320.43 ± 10.53
1367575_atNM_012554Enolase 1, alpha (glycolysis)Eno10.70 ± 0.070.62 ± 0.041.71 ± 0.081.62 ± 0.19
1388318_atBI279760Phosphoglycerate kinase 1 (glycolysis)Pgk10.81 ± 0.100.70 ± 0.102.08 ± 0.161.61 ± 0.20
1386864_atNM_053290Phosphoglycerate mutase 1 (glycolysis)Pgam10.71 ± 0.160.70 ± 0.071.53 ± 0.101.52 ± 0.06
1378382_atAI230014Phosphoglycerate mutase family member 5 (glycolysis)Pgam51.05 ± 0.050.91 ± 0.051.64 ± 0.041.61 ± 0.10
1391577_atBI293450Phosphoglycerate mutase family member 5 (glycolysis)Pgam51.12 ± 0.070.90 ± 0.051.56 ± 0.041.52 ± 0.24
1367864_atNM_031715Phosphofructokinase, muscle (glycolysis)Pfkm0.46 ± 0.110.43 ± 0.080.21 ± 0.040.23 ± 0.12
1372182_atBM389769Phosphofructokinase, platelet (glycolysis)Pfkp4.98 ± 0.724.95 ± 0.347.76 ± 0.716.09 ± 0.13
1387263_atNM_012624Pyruvate kinase, liver and red blood cell (glycolysis)Pklr0.51 ± 0.160.32 ± 0.220.15 ± 0.010.27 ± 0.06
1368651_atM17685Pyruvate kinase, liver and red blood cell (glycolysis)Pklr0.51 ± 0.060.52 ± 0.070.20 ± 0.020.22 ± 0.15
1370200_atBI284411Glutamate dehydrogenase 1Glud10.32 ± 0.060.24 ± 0.080.26 ± 0.010.31 ± 0.09
1387878_atAW916644Glutamate dehydrogenase 1Glud10.38 ± 0.060.26 ± 0.020.45 ± 0.040.43 ± 0.03
1370870_atM30596Malic enzyme 1Me10.51 ± 0.180.57 ± 0.090.54 ± 0.020.67 ± 0.08
1370067_atNM_012600Malic enzyme 1Me10.56 ± 0.130.63 ± 0.090.56 ± 0.030.84 ± 0.07
1386917_atNM_012744Pyruvate carboxylasePc0.38 ± 0.150.75 ± 0.100.47 ± 0.090.61 ± 0.10
1371388_atBM389223Pyruvate dehydrogenase (lipoamide) βPdhb0.58 ± 0.100.52 ± 0.080.74 ± 0.050.73 ± 0.07
1372229_atAI179119Pyruvate dehydrogenase kinase, isoenzyme 3 (mapped)Pdk30.21 ± 0.010.54 ± 0.120.09 ± 0.030.49 ± 0.04
1370848_atBI284218Solute carrier family 2 (facilitated glucose transporter), member 1Slc2a14.25 ± 0.372.22 ± 0.2812.80 ± 5.299.07 ± 2.86
1387228_atNM_012879Solute carrier family 2 (facilitated glucose transporter), member 2Slc2a20.37 ± 0.030.38 ± 0.040.27 ± 0.040.37 ± 0.08
Lipid metabolism
1367763_atD13921Acetyl-coenzyme A acetyltransferase 1Acat10.47 ± 0.000.59 ± 0.060.30 ± 0.050.23 ± 0.12
1383416_atAA899304Acetyl-coenzyme A acetyltransferase 1Acat10.32 ± 0.080.39 ± 0.120.36 ± 0.050.34 ± 0.05
1370939_atD90109Acyl-CoA synthetase long-chain family member 1Acsl10.78 ± 0.221.45 ± 0.110.61 ± 0.091.22 ± 0.05
1368177_atNM_057107Acyl-CoA synthetase long-chain family member 3Acsl30.78 ± 0.160.51 ± 0.101.92 ± 0.391.34 ± 0.33
1386926_atNM_053607Acyl-CoA synthetase long-chain family member 5Acsl51.67 ± 0.111.41 ± 0.152.35 ± 0.132.17 ± 0.15
1367854_atNM_016987ATP citrate lyaseAcly0.61 ± 0.060.66 ± 0.020.61 ± 0.010.71 ± 0.06
1398716_atBG670822Carnitine palmitoyltransferase 1a, liverCpt1a0.96 ± 0.410.79 ± 0.230.47 ± 0.040.43 ± 0.12
1382882_x_atAA963228Carnitine palmitoyltransferase 1a, liverCpt1a0.78 ± 0.040.78 ± 0.060.51 ± 0.070.44 ± 0.15
1392166_atBE099838Carnitine palmitoyltransferase 1a, liverCpt1a0.77 ± 0.190.83 ± 0.130.52 ± 0.030.48 ± 0.15
1397700_x_atBG670822Carnitine palmitoyltransferase 1a, liverCpt1a0.83 ± 0.470.91 ± 0.180.55 ± 0.050.40 ± 0.13
1386927_atNM_012930Carnitine palmitoyltransferase 2Cpt20.29 ± 0.080.31 ± 0.030.17 ± 0.040.21 ± 0.09
1367740_atM14400Ceatine kinase, brainCkb0.19 ± 0.070.15 ± 0.060.12 ± 0.030.09 ± 0.09
1390566_a_atBI301453Creatine kinase, mitochondrial 1, ubiquitousCkmt16.60 ± 0.945.46 ± 1.916.07 ± 1.563.82 ± 0.76
1391534_atBG666735Elongation of very-long-chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (predicted)Elovl2_predicted0.38 ± 0.280.36 ± 0.270.34 ± 0.040.39 ± 0.09
1388108_atBE116152ELOVL family member 6, elongation of long-chain fatty acids (yeast)Elovl60.43 ± 0.110.38 ± 0.080.36 ± 0.020.35 ± 0.06
1367857_atNM_053445Fatty acid desaturase 1Fads10.21 ± 0.070.25 ± 0.070.28 ± 0.030.27 ± 0.14
1367707_atNM_017332Fatty acid synthaseFasn0.33 ± 0.090.12 ± 0.080.50 ± 0.020.50 ± 0.14
1371979_atAI170663Sterol regulatory element– binding factor 2 (predicted)Srebf2_predicted0.87 ± 0.160.87 ± 0.040.45 ± 0.060.43 ± 0.08
1389611_atAA849857VLDL receptorVldlr0.75 ± 0.130.34 ± 0.122.39 ± 0.202.28 ± 0.07
1387455_a_atNM_013155VLDL lipoprotein receptorVldlr0.63 ± 0.150.50 ± 0.092.79 ± 0.252.35 ± 0.09
Chemokines/cytokines/adhesion molecules
1367973_atNM_031530Chemokine (C-C motif) ligand 2Ccl2962.7 ± 378.5987.1 ± 713.1511.9 ± 362.3124.1 ± 163.7
1369814_atAF053312Chemokine (C-C motif) ligand 20/Ccl20168.9 ± 15.5862.2 ± 119.2139.7 ± 15.9514.86 ± 5.29
1369983_atNM_031116Chemokine (C-C motif) ligand 5Ccl50.60 ± 1.5577.43 ± 32.634.42 ± 2.94182.1 ± 121.9
1379935_atBF419899Chemokine (C-C motif) ligand 7Ccl7131.3 ± 45.08128.0 ± 74.8559.30 ± 6.367.41 ± 2.48
1387316_atNM_030845Chemokine (C-X-C motif) ligand 1 (GRO-alpha)Cxcl1392.4 ± 101.836.4 ± 155.4189.8 ± 84.536.64 ± 3.37
1372064_atBI296385Similar to chemokine (C-X-C motif) ligand 16Cxcl1615.71 ± 2.7819.87 ± 3.5217.06 ± 1.3724.66 ± 2.03
1368760_atNM_031530Chemokine (C-X-C motif) ligand 2/Cxcl2282.1 ± 61.1715.91 ± 203.947.3 ± 21.721.54 ± 0.40
1373544_atAI170387Chemokine (C-X-C motif) ligand 9Cxcl9238.2 ± 232.7588.0 ± 339.3199.8 ± 88.6288.0 ± 161.2
1382454_atAI044222Chemokine (C-X-C motif) ligand 9Cxcl9290.5 ± 172.6913.8 ± 269.6197.2 ± 216.5334.7 ± 398.9
1387202_atNM_012967Intercellular adhesion molecule 1Icam1192.9 ± 29.93541.5 ± 110.693.2 ± 29.84152.8 ± 32.92
1368375_a_atAF015718IL-15Il1510.36 ± 0.4532.08 ± 1.366.84 ± 1.3720.42 ± 7.31
1368474_atNM_012889Vascular cell adhesion molecule 1Vcam13.13 ± 0.9534.83 ± 5.742.50 ± 0.8628.37 ± 12.45
IFN-γ signaling
1369956_atNM_053783IFN-γ receptor 1Ifngr1.47 ± 0.341.46 ± 0.281.81 ± 0.261.74 ± 0.15
1368073_atNM_012591IRF-1Irf166.39 ± 15.09105.83 ± 19.3419.85 ± 3.5634.76 ± 2.17
1371560_atAA893384IRF-3Irf30.81 ± 0.090.87 ± 0.230.70 ± 0.050.58 ± 0.06
1383564_atBF411036IRF- 7Irf790.31 ± 27.87427.28 ± 111.8822.64 ± 11.73104.71 ± 53.34
1372097_atBF284262IRF-8Irf881.26 ± 2.0157.63 ± 16.5912.28 ± 2.733.57 ± 2.74
1375796_atBI300770IFN-γ–induced GTPaseIgtp32.18 ± 11.5845.65 ± 10.407.96 ± 4.7611.24 ± 9.04
1373992_atAI408440Similar to IFN-inducible GTPaseMGC108823140.5 ± 42.77482.2 ± 131.4144.4 ± 18.54370.8 ± 95.71
1377950_atAA955213Similar to IFN-inducible GTPaseRGD130936263.4 ± 13.8235.0 ± 73.529.1 ± 11.5142.2 ± 43.5
1368835_atAW434718STAT1Stat114.50 ± 1.7519.51 ± 1.895.50 ± 0.698.67 ± 1.42
1372757_atBM386875STAT1Stat17.38 ± 0.858.27 ± 0.614.74 ± 0.497.28 ± 1.02
1387354_atNM_032612STAT1Stat128.13 ± 9.1623.80 ± 8.689.90 ± 1.9113.39 ± 4.09
1389571_atBG666368STAT2Stat217.98 ± 5.4325.50 ± 2.6832.83 ± 16.2349.37 ± 12.41
1370224_atBE113920STAT3Stat32.66 ± 0.432.86 ± 0.252.92 ± 0.661.91 ± 0.73
1371781_atBI285863STAT3Stat32.02 ± 0.152.96 ± 0.341.62 ± 0.221.66 ± 0.28
1387876_atAI177626STAT5BStat5b1.33 ± 0.391.23 ± 0.113.24 ± 1.021.41 ± 0.31
1383478_atBG671504Janus kinase 1Jak11.06 ± 0.160.98 ± 0.092.71 ± 0.112.74 ± 0.45
1384060_atBG663208Janus kinase 1Jak11.31 ± 0.040.97 ± 0.233.71 ± 0.383.38 ± 0.45
1368856_atNM_031514Janus kinase 2Jak29.74 ± 5.5817.88 ± 3.184.23 ± 1.485.79 ± 1.98
1380110_atAI229643Janus kinase 2Jak212.28 ± 1.1614.90 ± 2.817.27 ± 0.759.56 ± 1.54
1368251_atNM_012855Janus kinase 3Jak31.46 ± 0.123.24 ± 0.850.99 ± 0.241.53 ± 0.20
1376666_atAI170864Suppressor of cytokine signaling 6 (predicted)Socs6_predicted0.90 ± 0.171.28 ± 0.251.51 ± 0.081.37 ± 0.09
1391484_atBF284786Suppressor of cytokine signaling 7 (predicted)Socs7_predicted1.32 ± 0.061.53 ± 0.131.25 ± 0.031.41 ± 0.18
NF-κB regulation
1383474_atBI274988IL-1 receptor–associated kinase 2Irak23.55 ± 0.663.57 ± 1.513.01 ± 0.201.34 ± 0.23
1370968_atAA858801NFκ light-chain gene enhancer in B-cells 1, p105Nfkb119.06 ± 3.3017.76 ± 0.977.67 ± 1.597.48 ± 1.72
1389538_atAW672589NFκ light-chain gene enhancer in B-cells inhibitor, αNfkbia55.16 ± 26.2382.84 ± 18.9325.93 ± 8.4220.09 ± 5.05
1367943_atNM_030867NFκ light-chain gene enhancer in B-cells inhibitor, βNfkbib4.40 ± 1.975.78 ± 0.957.26 ± 2.315.67 ± 1.34
1375989_a_atAI170362NFκ light polypeptide gene enhancer in B-cells 2, p49/p100Nfkb212.32 ± 2.8418.22 ± 5.0210.63 ± 6.5511.33 ± 5.34
1376835_atBI293600NFκ light polypeptide gene enhancer in B-cells inhibitor, έNfkbie11.21 ± 3.3841.27 ± 4.762.04 ± 1.407.89 ± 1.86
1378032_atAI176265NFκ light polypeptide gene enhancer in B-cells inhibitor, ζ (predicted)Nfkbiz_predicted12.91 ± 2.159.86 ± 1.3613.48 ± 2.2610.71 ± 1.32
Others transcription factors
1379368_atAI237606B-cell leukemia/lymphoma 6 (predicted)Bcl6_predicted1.90 ± 0.902.23 ± 0.869.63 ± 1.5110.86 ± 2.22
1385592_atBI289386Bcl6 interacting corepressor (predicted)Bcor_predicted1.34 ± 0.041.53 ± 0.112.48 ± 0.521.76 ± 0.07
1391632_atAA964568CCAAT/enhancer binding protein (C/EBP), δCebpd0.74 ± 0.050.60 ± 0.032.21 ± 0.631.74 ± 0.09
1387343_atNM_013154CCAAT/enhancer binding protein (C/EBP), δCebpd2.34 ± 0.361.11 ± 0.1010.82 ± 3.475.42 ± 0.99
1375043_atBF415939FBJ murine osteosarcoma viral oncogene homologFos0.33 ± 0.080.70 ± 0.180.33 ± 0.070.29 ± 0.28
1388761_atAI180339Histone deacetylase 1 (predicted)Hdac1_predicted0.59 ± 0.040.72 ± 0.090.34 ± 0.050.56 ± 0.02
1396820_atAW530195Histone deacetylase 1 (predicted)Hdac1_predicted0.97 ± 0.160.99 ± 0.240.54 ± 0.020.56 ± 0.03
1370908_atAA892297Histone deacetylase 2Hdac20.61 ± 0.040.97 ± 0.160.73 ± 0.050.82 ± 0.02
1387076_atNM_024359HIF-1, α-subunitHif1a2.02 ± 0.171.58 ± 0.312.07 ± 0.202.16 ± 0.19
1369681_atNM_017339ISL1 transcription factor, LIM/homeodomain 1Isl10.53 ± 0.080.14 ± 0.050.31 ± 0.230.29 ± 0.06
1393138_atBE329377Jun D proto-oncogeneJund1.31 ± 0.101.43 ± 0.052.25 ± 0.231.83 ± 0.23
1369516_atNM_022852Pancreatic and duodenal homeobox gene 1Pdx11.01 ± 0.230.21 ± 0.030.49 ± 0.060.25 ± 0.21
1369242_atNM_013001Paired box gene 6Pax60.50 ± 0.010.52 ± 0.080.35 ± 0.040.53 ± 0.05
1374404_atBI288619Proto-oncogene c-junJun2.17 ± 1.362.44 ± 1.094.95 ± 0.942.76 ± 0.36
1369788_s_atNM_021835Proto-oncogene c-junJun4.71 ± 1.356.30 ± 1.777.39 ± 0.136.65 ± 1.20
1389528_s_atBI288619Proto-oncogene c-junJun4.00 ± 0.933.05 ± 0.689.12 ± 1.527.04 ± 2.01
Hormones
1387235_atNM_021655Chromogranin AChga0.64 ± 0.160.65 ± 0.010.30 ± 0.020.27 ± 0.05
1368034_atNM_012526Chromogranin BChgb0.79 ± 0.130.66 ± 0.020.30 ± 0.020.35 ± 0.04
1369888_atNM_012707GlucagonGcg0.71 ± 0.040.77 ± 0.060.10 ± 0.010.16 ± 0.06
1387815_atNM_019129Insulin 1Ins10.94 ± 0.091.04 ± 0.120.75 ± 0.060.79 ± 0.02
1370077_atNM_019130Insulin 2Ins20.86 ± 0.070.99 ± 0.090.68 ± 0.030.75 ± 0.01
1387660_atM25390Islet amyloid polypeptideIapp0.86 ± 0.100.85 ± 0.020.48 ± 0.030.60 ± 0.06
1368559_atNM_017091Proprotein convertase subtilisin/kexin type 1Pcsk10.48 ± 0.180.48 ± 0.070.18 ± 0.030.27 ± 0.05
1387247_atM83745Proprotein convertase subtilisin/kexin type 1Pcsk10.41 ± 0.140.56 ± 0.060.17 ± 0.020.23 ± 0.14
1387155_atNM_012746Proprotein convertase subtilisin/kexin type 2Pcsk20.78 ± 0.080.76 ± 0.080.45 ± 0.020.58 ± 0.04
1397662_atBF395791Proprotein convertase subtilisin/kexin type 2Pcsk20.92 ± 0.171.05 ± 0.080.26 ± 0.040.55 ± 0.14
1367778_atNM_019331Proprotein convertase subtilisin/kexin type 3Pcsk30.80 ± 0.060.51 ± 0.010.67 ± 0.050.57 ± 0.03
1367762_atNM_012659SomatostatinSst0.48 ± 0.060.48 ± 0.040.08 ± 0.010.08 ± 0.08
Hormone receptors
1369787_atNM_012688Cholecystokinin A receptorCckar0.23 ± 0.040.25 ± 0.040.06 ± 0.010.11 ± 0.12
1368481_atNM_012714Gastric inhibitory polypeptide receptorGipr0.55 ± 0.050.64 ± 0.160.14 ± 0.020.12 ± 0.08
1369699_atNM_012728GLP-1 receptorGlp1r0.47 ± 0.340.96 ± 0.260.32 ± 0.040.39 ± 0.08
1368924_atNM_017094Growth hormone receptorGhr0.41 ± 0.070.49 ± 0.170.31 ± 0.060.44 ± 0.07
1370384_a_atM57668Prolactin receptorPrlr0.36 ± 0.120.38 ± 0.180.17 ± 0.060.23 ± 0.20
1370789_a_atL48060Prolactin receptorPrlr0.15 ± 0.080.38 ± 0.140.21 ± 0.010.21 ± 0.05
1376944_atAI407163Prolactin receptorPrlr0.41 ± 0.030.49 ± 0.030.17 ± 0.040.35 ± 0.11
1392612_atAW142962Prolactin receptorPrlr0.37 ± 0.110.50 ± 0.120.13 ± 0.030.14 ± 0.10
1387177_atNM_017238Vasoactive intestinal peptide receptor 2Vipr20.35 ± 0.070.36 ± 0.060.13 ± 0.020.11 ± 0.03
Free radical scavanger/DNA damage
1367995_atNM_012520CatalaseCat0.79 ± 0.090.72 ± 0.091.96 ± 0.142.12 ± 0.29
1367774_atNM_031509Glutathione S-transferase A3Gsta30.58 ± 0.190.45 ± 0.166.34 ± 1.771.78 ± 0.13
1389832_atBE113459Glutathione S-transferase, ω 1Gsto10.62 ± 0.120.66 ± 0.041.54 ± 0.151.59 ± 0.05
1387023_atNM_031154Glutathione S-transferase, μ type 3Gstm30.38 ± 0.060.38 ± 0.040.14 ± 0.010.12 ± 0.05
1388122_atX02904Glutathione S-transferase, π 2Gstp20.83 ± 0.320.52 ± 0.144.61 ± 1.846.30 ± 2.10
1372016_atBI287978Growth arrest and DNA damage–inducible 45 βGadd45b44.52 ± 6.0221.01 ± 34.64131.03 ± 53.3838.81 ± 10.31
1388792_atAI599423Growth arrest and DNA damage–inducible 45 γGadd45g3.85 ± 1.062.43 ± 0.883.53 ± 0.481.89 ± 0.54
1388267_a_atM24327Metallothionein 1aMt1a2.41 ± 1.743.61 ± 1.2326.36 ± 4.4930.52 ± 4.33
1371237_a_atAF411318Metallothionein 1aMt1a3.02 ± 1.194.03 ± 1.0736.70 ± 11.3740.64 ± 9.73
1374911_atAW251534Oxidative stress responsive geneRGD13031421.01 ± 1.071.00 ± 0.348.43 ± 2.516.51 ± 0.66
1372941_atBI273897p53 and DNA damage regulated 1Pdrg12.01 ± 0.501.30 ± 0.032.61 ± 0.182.07 ± 0.07
1380071_atBI285978Poly (ADP-ribose) polymerase family, member 12 (predicted)Parp12_predicted7.04 ± 1.258.87 ± 0.942.89 ± 0.134.96 ± 0.65
1383251_atAW524533Poly (ADP-ribose) polymerase family, member 2 (predicted)Parp2_predicted0.99 ± 0.180.77 ± 0.201.22 ± 0.091.40 ± 0.13
1376144_atAA819679Poly (ADP-ribose) polymerase family, member 9 (predicted)Parp9_predicted27.68 ± 9.8248.25 ± 13.1915.17 ± 1.9422.40 ± 2.13
1370173_atBG671549Superoxide dismutase 2, mitochondrialSod26.74 ± 0.417.02 ± 0.197.51 ± 1.275.53 ± 0.35
1370172_atAA892254Superoxide dismutase 2, mitochondrialSod28.69 ± 0.509.23 ± 0.8213.07 ± 0.949.18 ± 0.63
Endoplasmic reticulum stress/apoptosis related
1369268_atNM_012912ATF3Atf315.73 ± 3.6923.27 ± 4.0053.89 ± 24.8726.59 ± 27.09
1367624_atNM_024403ATF4Atf41.33 ± 0.081.07 ± 0.052.32 ± 0.272.16 ± 0.12
1368066_atNM_053812BCL2-antagonist/killer 1Bak16.45 ± 3.375.77 ± 0.933.83 ± 0.766.81 ± 2.79
1369122_atAF235993Bcl2-associated X proteinBax1.17 ± 0.061.24 ± 0.062.34 ± 0.222.32 ± 0.22
1377759_atBG666928BH3-interacting domain death agonistBid6.29 ± 1.663.48 ± 1.369.39 ± 1.304.30 ± 0.71
1370283_atM14050BipHspa50.89 ± 0.100.91 ± 0.051.46 ± 0.031.35 ± 0.06
1370283_atM14050BipHspa50.89 ± 0.100.91 ± 0.051.46 ± 0.031.35 ± 0.06
1381173_atBG375010Caspase 4, apoptosis-related cysteine peptidaseCasp417.97 ± 7.5415.89 ± 5.155.70 ± 0.8917.31 ± 4.98
1387818_atNM_053736Caspase 4, apoptosis-related cysteine peptidaseCasp418.89 ± 7.2426.13 ± 13.1141.24 ± 27.8365.61 ± 19.29
1389170_atBF283754Caspase 7Casp70.40 ± 0.120.31 ± 0.180.57 ± 0.090.72 ± 0.08
1367529_atBE113989Derlin1RGD13118350.81 ± 0.060.78 ± 0.081.52 ± 0.201.44 ± 0.08
1374581_atBM384392Derlin1RGD13118350.91 ± 0.080.80 ± 0.091.73 ± 0.181.43 ± 0.13
1389615_atBI284801Derlin1RGD13118350.58 ± 0.190.55 ± 0.022.34 ± 0.252.07 ± 0.17
1369590_a_atNM_024134ChopDdit31.66 ± 0.271.19 ± 0.337.86 ± 1.117.10 ± 0.91
1383011_atAI501182Eukaryotic translation initiation factor 2AEif2a1.62 ± 0.091.62 ± 0.251.86 ± 0.201.70 ± 0.05
1388898_atAI236601Heat shock 105 kDa/110 kDa protein 1Hsph10.71 ± 0.080.74 ± 0.152.01 ± 0.661.50 ± 0.20
1385620_atBF525282Heat shock 105 kDa/110 kDa protein 1Hsph10.54 ± 0.070.31 ± 0.153.56 ± 0.851.35 ± 0.20
1388721_atBG380282Heat shock 22 kDa protein 8Hspb835.81 ± 13.5412.67 ± 5.189.02 ± 2.865.92 ± 2.36
1368247_atNM_031971Heat shock 70 kD protein 1AHspa1a1.21 ± 0.161.25 ± 0.235.57 ± 1.021.52 ± 1.14
1370912_atBI278231Heat shock 70 kD protein 1B (mapped)Hspa1b1.19 ± 0.261.17 ± 0.356.15 ± 1.092.03 ± 1.48
1388851_atBI282281Heat shock 70 kDa protein 9A (predicted)Hspa9a_predicted0.80 ± 0.070.69 ± 0.031.97 ± 0.101.91 ± 0.12
1386894_atNM_022229Heat shock protein 1 (chaperonin)Hspd10.52 ± 0.010.49 ± 0.011.37 ± 0.111.24 ± 0.05
1372701_atAI237597Heat shock protein 1, αHspca0.76 ± 0.120.76 ± 0.182.79 ± 0.201.63 ± 0.26
1388850_atBG671521Heat shock protein 1, αHspca0.67 ± 0.060.79 ± 0.093.06 ± 0.681.66 ± 0.27
1398240_atNM_024351Heat shock protein 8Hspa80.66 ± 0.060.68 ± 0.081.51 ± 0.101.21 ± 0.05
1368195_atNM_134419Hspb-associated protein 1Hspbap10.81 ± 0.771.00 ± 0.253.89 ± 0.302.22 ± 0.34
1370174_atBI284349Myeloid differentiation primary response gene 116Myd1166.11 ± 0.816.55 ± 4.6121.46 ± 2.399.67 ± 6.56
1382615_atBI284366Sec61 α1 subunit (S. cerevisiae)Sec61a10.76 ± 0.180.97 ± 0.090.75 ± 0.290.54 ± 0.04
1375659_atBG381529Sec61, α-subunit 2 (S. cerevisiae) (predicted)Sec61a2_predicted0.77 ± 0.060.84 ± 0.030.71 ± 0.040.81 ± 0.01
1372533_atAI175790Similar to mKIAA0212 protein (predicted)edem1.35 ± 0.122.06 ± 0.141.44 ± 0.051.51 ± 0.16
1370695_s_atAB020967Tribbles homolog 3 (Drosophila)Trib31.88 ± 0.760.88 ± 0.138.15 ± 3.617.74 ± 0.85
1370694_atAB020967Tribbles homolog 3 (Drosophila)Trib31.94 ± 1.041.16 ± 0.239.76 ± 1.287.81 ± 0.47
1386321_s_atH31287Tribbles homolog 3 (Drosophila)Trib32.12 ± 0.611.30 ± 0.1614.66 ± 2.3210.47 ± 1.31
1369065_a_atNM_017290Serca2Atp2a20.40 ± 0.080.45 ± 0.070.21 ± 0.020.25 ± 0.07
1370426_a_atAI175492Serca2Atp2a20.51 ± 0.060.52 ± 0.030.63 ± 0.060.65 ± 0.03
Cell cycle
1390343_atAA998893Cyclin CCcnc0.61 ± 0.150.59 ± 0.030.48 ± 0.010.68 ± 0.04
1389101_atBE120340Cyclin CCcnc0.90 ± 0.140.81 ± 0.211.33 ± 0.211.62 ± 0.04
1371643_atAW143798Cyclin D1Ccnd10.48 ± 0.120.69 ± 0.140.43 ± 0.120.55 ± 0.17
1369935_atNM_012766Cyclin D3Ccnd30.38 ± 0.110.52 ± 0.020.62 ± 0.120.62 ± 0.10
1371953_atAI408309Cyclin G2 (predicted)Ccng2_predicted4.59 ± 0.724.51 ± 1.852.45 ± 0.332.54 ± 0.37
1388370_atAA945706Cyclin I (predicted)Ccni_predicted0.93 ± 0.061.05 ± 0.060.74 ± 0.020.88 ± 0.04
1368050_atNM_053662Cyclin L1Ccnl11.61 ± 0.351.96 ± 0.552.76 ± 0.471.80 ± 0.76
1390815_atBF282870Cyclin M1 (predicted)Cnnm1_predicted1.08 ± 0.110.76 ± 0.170.49 ± 0.040.38 ± 0.05
1391270_atBE112177Cyclin M3 (predicted)Cnnm3_predicted0.37 ± 0.050.33 ± 0.050.19 ± 0.040.37 ± 0.07
1384214_a_atAI045459Cyclin T2 (predicted)Ccnt2_predicted0.50 ± 0.230.75 ± 0.300.27 ± 0.060.42 ± 0.09
1390470_atBE107044Cyclin T2 (predicted)Ccnt2_predicted1.73 ± 0.291.21 ± 0.120.53 ± 0.090.71 ± 0.16
Splicing machinery
Serine-rich and serine-rich–related protein
1376252_atAI145784Splicing factor, arginine/serine-rich 3 (SRp20) (predicted)Sfrs3_predicted1.03 + 0.080.76 + 0.270.39 + 0.020.50 + 0.12
1379010_atAA956727Splicing factor, arginine/serine-rich 3 (SRp20) (predicted)Sfrs3_predicted2.11 + 0.431.18 + 0.283.98 + 0.872.05 + 0.67
1376594_atAW524517Similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)Vezf1_predicted1.73 + 0.601.45 + 0.233.16 + 0.363.44 + 0.51
1383537_atBF522715Similar to splicing factor, arginine/serine-rich 1 (ASF/SF2)Vezf1_predicted1.84 + 0.461.79 + 0.301.67 + 0.291.80 + 0.11
1371838_atAI411155Similar to splicing factor, arginine/serine-rich 2Sfrs21.11 + 0.071.13 + 0.121.43 + 0.041.33 + 0.04
1371839_atAA819369Similar to splicing factor, arginine/serine-rich 2Sfrs20.63 + 0.130.66 + 0.071.59 + 0.101.33 + 0.17
1368992_a_atAI104005Splicing factor, arginine/serine-rich 5Sfrs50.56 + 0.090.77 + 0.170.53 + 0.030.57 + 0.06
1371999_atBI303641Splicing factor arginine/serine-rich 6 (SRP55-2) (isoform 2)Sfrs60.37 + 0.130.71 + 0.060.19 + 0.040.20 + 0.09
1381623_atBF391476Ssimilar to Sfrs4 protein (predicted)Sfrs4_predicted1.23 + 0.371.59 + 0.142.08 + 0.221.89 + 0.17
1370188_atAW252670Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)Sfrs101.02 + 0.161.04 + 0.062.18 + 0.291.41 + 0.13
1371425_atBF396399Serine/arginine repetitive matrix 1 (predicted)Srrm1_predicted1.29 + 0.211.20 + 0.131.40 + 0.091.37 + 0.06
1383410_atBI290777Signal recognition particle 54Srp540.91 + 0.090.88 + 0.061.50 + 0.131.21 + 0.03
1371596_atAI008971Ribonucleic acid binding protein S1Rnps11.01 + 0.340.90 + 0.121.84 + 0.081.54 + 0.06
Heterogeneous nuclear ribonucleoprotein family
1398883_atBI296284Heterogeneous nuclear ribonucleoprotein A2/B1 (predicted)Hnrpa2b1_predicted0.77 + 0.100.85 + 0.050.45 + 0.040.53 + 0.06
1371505_atBG381750Heterogeneous nuclear ribonucleoprotein CHnrpc1.15 + 0.031.15 + 0.062.25 + 0.282.05 + 0.18
1367931_a_atX60790Polypyrimidine tract binding protein 1Ptbp10.67 + 0.120.60 + 0.020.83 + 0.140.73 + 0.10
1370919_atAI103467Heterogeneous nuclear ribonucleoprotein MHnrpm0.85 + 0.090.81 + 0.030.79 + 0.070.78 + 0.07
Other splicing factors
1389975_atBE116949ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)HuD0.63 + 0.120.59 + 0.110.32 + 0.020.33 + 0.06
1394546_atAI556229ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)HuD0.82 + 0.370.59 + 0.030.10 + 0.010.21 + 0.09
1395083_atAA926313Neuro-oncological ventral antigen 1Nova10.34 + 0.180.68 + 0.180.22 + 0.030.37 + 0.11
1388476_atAI101391Tial1 cytotoxic granule–associated RNA binding protein–like 1 (mapped)Tial11.15 + 0.211.03 + 0.211.39 + 0.021.32 + 0.05
1374463_atAI172068Quaking homolog, KH domain RNA binding (mouse)Qki1.33 + 0.041.07 + 0.221.87 + 0.081.57 + 0.16
1370899_atAI599699Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)Sfpq0.42 + 0.050.48 + 0.020.40 + 0.080.30 + 0.13
1386896_atAF393783KH domain containing, RNA binding, signal transduction–associated 1Khdrbs10.88 + 0.120.82 + 0.042.15 + 0.191.66 + 0.17
1398773_atNM_130405KH domain containing, RNA binding, signal transduction–associated 1Khdrbs10.96 + 0.180.96 + 0.041.31 + 0.061.39 + 0.05
1372496_atBG371538Ribonucleoprotein PTB-binding 1 (protein raver-1)Raver1h0.55 + 0.240.68 + 0.073.26 + 0.381.85 + 0.29
1371367_atBE107459TAR DNA-binding protein 43 (TDP-43)Tardbp0.93 + 0.070.83 + 0.100.40 + 0.030.51 + 0.05
  • Data are means ± SE of three independent experiments and are expressed as fold change versus control cells, studied at the same time points. Gene expression was considered modified by cytokines when P ≤ 0.02 (paired t test) and expression level ≥ 1.5-fold higher or lower as compared with control conditions. Primary rat β-cells were left untreated or exposed to IL1β + IFN-γ (IL + IFN) or TNF-α + IFN-γ (TNF + IFN) for 6 and 24 h.