TABLE 2

Metabolic parameters during the euglycemic-hyperinsulinemic clamp before and after 1-year lifestyle intervention

Men (n = 26)Women (n = 32)
Baseline1 yearBaseline1 year
Postabsorptive state
    Glucose (μmol/l)*8.2 ± 0.46.7 ± 0.37.8 ± 0.37.3 ± 0.3
    Insulin (pmol/l)*71.1 ± 7.252.5 ± 8.991.5 ± 6.580.0 ± 8.0
    FFAs (mmol/l)*0.56 ± 0.020.45 ± 0.030.79 ± 0.030.63 ± 0.02
Steady state during clamp
    Glucose (μmol/l)5.7 ± 0.15.7 ± 0.15.8 ± 0.15.8 ± 0.1
    Insulin (pmol/l)†834.3 ± 49.1820.1 ± 39.2982.9 ± 44.2859.5 ± 35.3
    FFAs (mmol/l)*0.03 ± 0.010.01 ± 0.000.05 ± 0.060.02 ± 0.003
    GDR (mg · kg FFM−1 · min−1)*5.7 ± 0.48.9 ± 0.56.2 ± 0.48.4 ± 0.5
    Glucose oxidation (mg · kg FFM−1 · min−1)*‡2.7 ± 0.13.4 ± 0.23.1 ± 0.23.8 ± 0.2
    Glucose storage (mg · kg FFM−1 · min−1)*‡3.0 ± 0.35.5 ± 0.42.9 ± 0.44.4 ± 0.5
  • Values are unadjusted means ± SE.

  • *Significant change in both men and women (P range <0.05 to 0.00001), with no significant interaction by sex.

  • †Significant change in women only (P < 0.05).

  • ‡Men, n = 26; women, n = 30.