TABLE 1

General assessment parameters in each of the study groups

NondiabeticNondiabetic + AM251DiabeticDiabetic + AM251
Body wt (g)28.71 ± 1.1329.41 ± 0.5625.23 ± 0.84*25.86 ± 0.69*
Blood glucose (mg/dl)120 ± 5.81104 ± 12.07411 ± 36.07†386 ± 36.64†
Glycated Hb (%)4.23 ± 0.054.40 ± 0.1612.93 ± 0.32†12.49 ± 0.24†
sBP (mmHg)101 ± 3.3098 ± 3.30119 ± 10.50118 ± 3.79
Kidney/body wt6.62 ± 0.036.46 ± 0.198.42 ± 0.997.34 ± 0.29
AER (μg/18 h)33.4 (25.1–40.2)37.5 (12.6–126.4)336.6 (164.9–778.5)†153.1 (70.7–298.1)†‡
  • Data are shown as means ± SE orgeometric mean (25th–75th percentile). sBP, systolic blood pressure; AER, albumin excretion rate.

  • *P < 0.05 diabetic and diabetic + AM251 vs. nondiabetic and nondiabetic + AM251;

  • P < 0.001 diabetic and diabetic + AM251 vs. nondiabetic and nondiabetic + AM251;

  • P < 0.01 diabetic + AM251 vs. diabetic.