TABLE 2

Association of LDL measures with incident type 2 diabetes

Quintile 1Quintile 2Quintile 3Quintile 4Quintile 5P for trend
LDL cholesterol (mg/dl)≤97.397.4–115.2115.3–131.9132.0–153.7>153.7
    Model 1Referent0.99 (0.85–1.16)1.14 (0.98–1.33)1.10 (0.94–1.29)1.57 (1.35–1.82)<0.001
    Model 2Referent0.94 (0.80–1.11)0.94 (0.80–1.10)0.85 (0.72–1.00)1.08 (0.93–1.26)0.64
LDLNMR particle concentrations
    Total LDLNMR (nmol/l)≤957958–1,1551,156–1,3731,374–1,680>1,680
        Model 1Referent1.31 (1.02–1.68)2.29 (1.83–2.87)3.78 (3.05–4.67)6.49 (5.29–7.96)<0.001
        Model 2Referent1.07 (0.83–1.38)1.48 (1.18–1.87)1.83 (1.47–2.28)2.53 (2.04–3.13)<0.001
    Large LDLNMR (nmol/l)≤361362–476477–577578–698>698
        Model 14.25 (3.64–4.97)1.90 (1.59–2.26)1.55 (1.29–1.86)1.27 (1.05–1.53)Referent<0.001
        Model 22.50 (2.12–2.95)1.44 (1.20–1.73)1.37 (1.14–1.66)1.27 (1.04–1.54)Referent<0.001
    Small LDLNMR (nmol/l)≤346347–553554–774775–1,134>1,134
        Model 1Referent1.85 (1.42–2.40)3.00 (2.35–3.83)5.20 (4.13–6.55)10.19 (8.17–12.72)<0.001
        Model 2Referent1.54 (1.18–2.02)2.09 (1.63–2.68)2.62 (2.06–3.32)4.04 (3.21–5.09)<0.001
    IDLNMR (nmol/l)≤56–2021–3940–72>72
        Model 1Referent1.27 (1.04–1.56)1.75 (1.45–2.12)2.22 (1.85–2.66)3.07 (2.58–3.65)<0.001
        Model 2Referent1.16 (0.94–1.42)1.35 (1.11–1.65)1.40 (1.16–1.68)1.66 (1.39–1.99)<0.001
LDLNMR average size (nm)≤20.520.6–21.021.1–21.521.6–21.9>21.9
    Model 19.99 (8.03–12.44)5.54 (4.41–6.96)3.07 (2.44–3.88)1.83 (1.41–2.38)Referent<0.001
    Model 24.16 (3.30–5.24)3.04 (2.40–3.86)2.21 (1.74–2.81)1.63 (1.25–2.13)Referent<0.001
  • Data are HR (95% CI) and (ranges minimum–maximum) and are given for each quintile. P for trend obtained from using median quantile as a dependent variable in Cox regression models. Model 1: adjusted for age, race, and randomized treatment assignment. Model 2: adjusted for model 1 variables plus smoking, exercise, education, menopausal status, hormone use, blood pressure, BMI, family history of diabetes, A1C, and hsCRP.