TABLE 3

Association of HDL measures with incident type 2 diabetes

Quintile 1Quintile 2Quintile 3Quintile 4Quintile 5P for trend
HDL cholesterol (mg/dl)≤39.839.9–46.346.4–52.852.9–61.8>61.8
    Model 19.52 (7.89–11.48)5.32 (4.37–6.48)2.94 (2.38–3.63)1.84 (1.47–2.30)Referent<0.001
    Model 24.01 (3.28–4.92)3.14 (2.56–3.86)2.05 (1.65–2.55)1.54 (1.23–1.93)Referent<0.001
HDLNMR particle concentrations
    Total HDLNMR (μmol/l)≤29.029.1–31.932.0–34.334.4–37.3>37.3
        Model 11.60 (1.39–1.83)1.21 (1.04–1.40)1.07 (0.92–1.24)1.01 (0.88–1.17)Referent<0.001
        Model 21.20 (1.03–1.40)1.07 (0.91–1.25)0.91 (0.77–1.07)0.88 (0.75–1.02)Referent0.008
    Large HDLNMR (μmol/l)≤44.1–5.85.9–7.77.8–10.0>10.0
        Model 19.89 (8.20–11.93)5.36 (4.39–6.55)3.31 (2.69–4.08)1.84 (1.47–2.31)Referent<0.001
        Model 24.51 (3.68–5.52)3.19 (2.58–3.94)2.54 (2.04–3.15)1.72 (1.36–2.17)Referent<0.001
    Medium HDLNMR (μmol/l)≤0.20.3–1.41.5–3.03.1–5.6>5.6
        Model 1Referent1.19 (1.01–1.41)1.23 (1.04–1.46)1.20 (1.01–1.41)1.11 (0.95–1.30)0.47
        Model 2Referent1.14 (0.96–1.35)1.01 (0.84–1.20)1.04 (0.87–1.23)1.03 (0.87–1.21)0.72
    Small HDLNMR (μmol/l)≤18.818.9–21.922.0–24.424.5–27.3>27.3
        Model 1Referent1.46 (1.20–1.77)1.69 (1.40–2.04)2.21 (1.85–2.65)2.68 (2.25–3.18)<0.001
        Model 2Referent1.19 (0.97–1.45)1.36 (1.12–1.65)1.51 (1.25–1.81)1.84 (1.54–2.19)<0.001
HDLNMR average size (nm)≤8.58.6–8.78.8–9.09.1–9.4>9.4
    Model 112.01 (9.31–15.50)9.04 (6.95–11.75)4.78 (3.67–6.23)2.10 (1.59–2.79)Referent<0.001
    Model 24.56 (3.50–5.93)3.97 (3.03–5.21)3.08 (2.35–4.03)1.72 (1.29–2.29)Referent<0.001
  • Data are adjusted HR (95% CI) and (ranges minimum–maximum) and are given for each quintile. See Table 2 legend for model adjustments.