TABLE 4

Association of VLDL measures with incident type 2 diabetes

Quintile 1Quintile 2Quintile 3Quintile 4Quintile 5P for trend
Triglycerides (mg/dl)≤7071–9596–125126–178>178
    Model 1Referent1.73 (1.30–2.31)2.47 (1.88–3.25)4.91 (3.81–6.33)8.88 (6.94–11.37)<0.001
    Model 2Referent1.36 (1.01–1.83)1.57 (1.18–2.08)2.57 (1.98–3.35)3.71 (2.87–4.80)<0.001
VLDLNMR particle concentrations
    Total VLDLNMR (nmol/l)≤45.645.7–61.861.9–77.277.3–96.8>96.8
        Model 1Referent1.41 (1.19–1.67)1.62 (1.38–1.91)1.70 (1.44–2.00)1.81 (1.54–2.13)<0.001
        Model 2Referent1.18 (0.99–1.41)1.16 (0.98–1.38)1.25 (1.05–1.48)1.26 (1.06–1.50)0.01
    Large VLDLNMR (nmol/l)≤0.10.2–0.50.6–1.81.9–3.8>3.8
        Model 1Referent1.58 (1.16–2.14)3.57 (2.71–4.70)5.41 (4.12–7.09)6.66 (5.10–8.70)<0.001
        Model 2Referent1.49 (1.09–2.05)2.54 (1.91–3.39)2.98 (2.24–3.96)3.11 (2.35–4.11)<0.001
    Medium VLDLNMR (nmol/l)≤8.28.3–15.916.0–23.823.9–34.1>34.1
        Model 1Referent1.11 (0.95–1.30)1.08 (0.92–1.27)1.07 (0.91–1.26)1.15 (0.98–1.35)0.19
        Model 2Referent1.03 (0.88–1.22)0.99 (0.84–1.18)0.89 (0.75–1.05)1.04 (0.88–1.23)0.73
    Small VLDLNMR (nmol/l)≤31.531.6–42.142.2–51.551.6–63.1>63.1
        Model 1Referent1.50 (1.28–1.76)1.69 (1.44–1.98)1.79 (1.53–2.11)1.87 (1.59–2.20)<0.001
        Model 2Referent1.13 (0.96–1.34)1.11 (0.94–1.31)1.22 (1.03–1.44)1.31 (1.10–1.55)0.001
    VLDLNMR average size (nm)≤40.640.7–43.843.9–47.347.4–52.0>52.0
        Model 1Referent1.23 (0.96–1.58)1.96 (1.56–2.46)3.31 (2.68–4.09)4.93 (4.03–6.04)<0.001
        Model 2Referent1.25 (0.97–1.62)1.67 (1.32–2.10)2.22 (1.78–2.76)2.80 (2.27–3.46)<0.001
  • Data are adjusted HR (95% CI) and (ranges minimum–maximum) and are given for each quintile. See Table 2 legend for model adjustments.