TABLE 1

Effect of 15-day rapamycin treatment on weight, food intake, and metabolic parameters of treated rats

ControlRapamycin
Body weight (g)303.6 ± 3.68226.3 ± 4.34***
Weight gain (g)91.4 ± 3.5712.8 ± 3.87***
Food intake (g)256.4 ± 6.53217.7 ± 8.53**
Food efficiency (body weight gain/food intake)0.117 ± 0.0040.019 ± 0.006***
Glucose (mmol/l)8.5 ± 0.3313.3 ± 2.53*
Insulin (pmol/l)351.5 ± 58.71,265.1 ± 395.1*
Glucagon (ng/l)127.25 ± 10.65130.47 ± 14.33
Triglycerides (mmol/l)0.644 ± 0.0500.848 ± 0.060*
NEFAs (mmol/l)0.115 ± 0.0200.190 ± 0.040*
Glycerol (mg/dl)1.025 ± 0.0841.177 ± 0.107
Lactate (mmol/l)0.904 ± 0.0500.852 ± 0.039
Adiponectin (μg/ml)11.89 ± 1.5312.11 ± 0.83
Leptin (ng/ml)9.48 ± 1.864.94 ± 1.51*
  • Data are average ± SE (n = 12 control, n = 10 for rapamycin). Refed plasma data are average ± SE (n = 6–12 for control, n = 6–10 for rapamycin).

  • *P ≤ 0.05,

  • **P ≤ 0.01,

  • ***P ≤ 0.001 vs. control. NEFAs, nonesterified fatty acids.