TABLE 1

Hyperinsulinemic-euglycemic clamp measurements

B6-dbBKS-db
n86
Body weight (g)22.1 ± 0.522.5 ± 0.7
Fat mass (g)8.0 ± 0.47.9 ± 0.5
Lean mass (g)12.6 ± 0.412.5 ± 0.5
Basal glucose (mg/dl)125 ± 10116 ± 19
Basal insulin (pmol/l)328 ± 63324 ± 53
Clamp glucose (mg/dl)125 ± 7135 ± 9
Clamp insulin (pmol/l)1,882 ± 1361,829 ± 258
Glucose infusion rate (mg/kg/min)7.2 ± 0.921.3 ± 2.8*
Whole-body glucose turnover (mg/kg/min)30.8 ± 1.440.6 ± 3.2
Whole-body glycolysis (mg/kg/min)24.2 ± 2.128.9 ± 1.0
Whole-body glycogen synthesis (mg/kg/min)6.6 ± 2.011.7 ± 3.3
Muscle glucose uptake (nmol/g/min)162 ± 20314 ± 46
Suppression of hepatic glucose production (%)00
  • Data are means ± SE.

  • *P < 0.0005;

  • P < 0.05.