TABLE 2

AUC values

Day 1Day 2Day 3Day 4Day 5
Glucose (mol/l · 120 min)1.4 ± 0.1*21.6 ± 0.1*1,3,51.4 ± 0.1*21.5 ± 0.11.4 ± 0.1*2
GLP-1 (nmol/l · 120 min)20 ± 218 ± 1
Glucagon (nmol/l · 120 min)−0.9 ± 0.1*2,42 ± 0.5*1,3,5−1.4 ± 0.1*2,42 ± 0.6*1,3,5−1.2 ± 0.1*2,4
Insulin (nmol/l · 120 min)37 ± 11*2,31.1 ± 1*1,4,5−1.1 ± 1*1,4,525 ± 2*2,324 ± 2*2,3
C-peptide (nmol/l · 120 min)215 ± 39*2,3,4,5−56 ± 5*1−80 ± 7*1−76 ± 6*1−82 ± 8*1
  • Data shown are means ± SE. Differences between the five days were evaluated for significance (P < 0.05) using repeated-measures ANOVA with Tukey post hoc analysis. Glucose is shown as total AUC; GLP-1, glucagon, insulin, and C-peptide as incremental/decremental AUCs. Significant differences are indicated by asterisks (*) followed by the number(s) of the group(s) compared with. Day 1: GLP-1 (insulin stimulation, glucagon inhibition); day 2: GLP-1, somatostatin, basal insulin, basal glucagon; day 3: somatostatin, basal insulin; day 4: somatostatin, “stimulated” insulin (mimicking day 1-insulin response), basal glucagon; and day 5: somatostatin, “stimulated” insulin (mimicking Day 1-insulin response).