TABLE 1

Subjects' characteristics, metabolic variables, and body composition

PlaceboTUDCA
BeforeAfterBeforeAfter
n (male/female)10 (4/6)10 (4/6)
Age (years)49 ± 1447 ± 9
BMI (kg/m2)37 ± 538 ± 535 ± 335 ± 3
Total body mass (kg)109 ± 18110 ± 17100 ± 12100 ± 12
Fat mass (%)39 ± 739 ± 739 ± 839 ± 8
Subcutaneous abdominal fat volume (cm3)5,087 ± 1,7494,999 ± 1,6724,803 ± 1,2024,716 ± 1,188
Intra-abdominal fat volume (cm3)2,146 ± 7892,172 ± 7162,724 ± 8462,818 ± 924
IHTG content (%)14.0 ± 10.713.7 ± 9.68.2 ± 5.59.3 ± 7.2
HOMA-IR4.2 ± 1.84.3 ± 1.74.4 ± 2.73.8 ± 3.4
Plasma concentrations
    Glucose (mg/dl)97 ± 997 ± 1096 ± 994 ± 5
    Insulin (μU/ml)18 ± 718 ± 719 ± 1216 ± 15
    FFAs (mmol/l)0.59 ± 0.130.63 ± 0.150.62 ± 0.150.62 ± 0.19
    Triglycerides (mg/dl)154 ± 52145 ± 77136 ± 67141 ± 66
    AST (IU/l)25.9 ± 10.327.9 ± 14.522.4 ± 5.922.5 ± 6.1
    ALT (IU/l)30.3 ± 24.735.6 ± 34.926.9 ± 9.624.6 ± 8.1
    CRP (mg/l)5.67 ± 5.695.00 ± 3.875.40 ± 4.114.43 ± 2.94
    IL-6 (pg/ml)2.60 ± 0.952.44 ± 0.862.32 ± 0.652.60 ± 1.17
    Total adiponectin (mg/l)6.7 ± 3.86.9 ± 4.68.3 ± 3.18.3 ± 3.1
    HMW adiponectin (mg/l)2.2 ± 2.62.2 ± 2.93.1 ± 1.93.4 ± 2.4
  • Data are means ± SD. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; HMW, high molecular weight; IL, interleukin.