TABLE 1

Basal and clamp characteristics of DIO rats receiving continuous intracerebroventricular infusion of either hFGF21 or vehicle

VehiclehFGF21
n67
Basal
    Body weight (g)527.1 ± 18.9561.1 ± 26.7
    Δ Body weight (g)−23.0 ± 3.2−25.6 ± 4.4
    HFD intake (g/5 days)62.6 ± 4.284.6 ± 4.8*
    Plasma hFGF21N.D.N.D.
    Arterial plasma glucose (mg/dl)112.2 ± 4.0104.0 ± 5.0
    Plasma insulin (ng/ml)2.40 ± 0.682.12 ± 0.54
    Plasma nonesterified fatty acids (mmol/l)0.39 ± 0.0200.41 ± 0.014
    Plasma triglycerides (mg/dl)41.0 ± 4.348.3 ± 6.0
Clamp
    Arterial plasma glucose (mg/dl)110.7 ± 5.4116.0 ± 2.4
    Plasma insulin (ng/ml)6.6 ± 0.357.1 ± 0.90
    GIR (mg/kg/min)2.6 ± 0.244.4 ± 0.10*
    Hepatic glycogen (ng/mg tissue)144.1 ± 12.4152.7 ± 12.5
  • Data are means ± SEM. N.D., not determined.

  • *P < 0.05 vs. vehicle.