TABLE 1

Proband and affected family-based control (AFBAC) HLA DPA1, DPB1 allele, and DPA1-DPB1 haplotype frequency distribution in 1,771 type 1 diabetes families

AFBAC (%) (n = 2,759)Proband (%) (n = 3,542)PadjOdds Ratio95% CIAFBAC (%) (n = 2,759)Proband (%) (n = 3,542)PadjOdds Ratio95% CI
DPA1*
    010382.483.61.1
    01040.51.12.01.1–3.6
    020113.713.51.00.8–1.2
    02023.21.62E-40.50.4–0.7
DPB1*DPA1*-DPB1*
    01015.67.40.051.41.1–1.70103-01011.30.60.50.3–0.8
0201-01013.46.42E-61.91.5–2.5
0202-01010.90.40.50.2–0.9
    020113.515.21.11.0–1.40103-020112.614.91.21.0–1.4
    02020.72.87E-94.42.6–7.30103-02020.52.85E-105.33.0–9.1
    030110.415.95E-81.61.4–1.90103-030110.115.62E-81.71.4–2.0
    040142.040.20.90103-040140.839.30.9
    040211.55.39E-170.40.4–0.50103-040211.25.11E-160.40.3–0.5
    10011.81.00.040.50.3–0.80103-06011.52.21.51.0–2.2
    11012.10.99E-40.40.3–0.70201-10011.50.90.60.4–0.9
    14011.30.80.60.4–1.00201-11011.70.80.020.50.3–0.8
    15010.71.52.11.2–3.50104-15010.51.02.01.0–3.7
    17011.71.00.60.4–0.90201-17011.61.00.60.4–1.0
  • Only alleles or haplotypes with a frequency >5% in an individual category or >1% where the nominal P value was <0.05 were compared. The nominal P value was adjusted (Padj) for multiple alleles or haplotypes by applying the Bonferroni correction of multiplying the nominal P value by the number of alleles or haplotypes compared.