TABLE 2

Expected and observed proband DPA1, DPB1, and DPA1-DPB1 frequencies conditioned on HLA DRB1-DQA1-DQB1 linkage disequilibrium in 1,771 type 1 diabetes families

Proband Fexp (%)Proband Fobs (%)PadjOdds Ratio (Fobs/Fexp)95% CIProband Fexp (%)Proband Fobs (%)PadjOdds Ratio (Fobs/Fexp)95% CI
DPA1*DPA1-DPB1
    010380.382.81.2
    01040.51.02.01.1–3.7
    020117.213.45E-40.70.6–0.9
    02022.02.81.41.0–2.0
DPB1*
    010111.48.02E-40.70.6–0.80103-01012.80.72E-100.20.1–0.4
0201-01017.56.30.80.7–1.0
    020113.015.21.21.0–1.40103-020112.114.71.31.1–1.5
    02021.42.82E-32.01.4–3.00103-02021.42.82E-32.11.4–3.0
    030110.115.64E-81.61.4–2.00103-030110.015.35E-81.61.4–1.9
    040140.839.91.00103-040138.938.71.00.9–1.1
0201-04011.20.70.60.3–1.0
    040210.95.32E-140.50.4–0.60103-040210.75.17E-150.50.4–0.5
    05011.11.71.61.0–2.5
    06011.52.21.51.0–2.30103-06011.42.21.61.1–2.3
    10011.71.00.60.4–0.90201-10011.70.90.050.50.3–0.8
    11011.60.90.50.3–0.90201-11011.60.80.030.50.3–0.8
    15010.51.52E-33.01.6–5.40104-15010.51.021.1–3.7
  • Only alleles or haplotypes with a frequency >5% in an individual category or >1% where the nominal P value was <0.05 were compared. The nominal P value was adjusted (Padj) for multiple alleles or haplotypes by applying the Bonferroni correction of multiplying the nominal P value by the number of alleles or haplotypes compared.