TABLE 3

Relative predispositional analysis; DPA1, DPB1 allele, and DPA1-DPB1 haplotype frequency distribution in 1,771 type 1 diabetes families in the presence or absence of the high-risk and protective DRB1-DQA1-DQB1 haplotypes

Presence of high-risk and protective DR-DQ haplotypesAbsence of high-risk and protective DR-DQ haplotypes
% AFBACs (n = 1,102)% Probands (n = 2,626)PadjOdds Ratio95% CI% AFBACs (n = 1,656)% Probands (n = 916)PadjOdds Ratio95% CI
DPA1*
    010383.783.71.081.583.41.11.0–1.2
    01040.72.20.0023.31.6–7.0
    020114.214.41.00.8–1.313.310.90.80.6–1.0
DPB1*
    01019.59.31.00.8–1.3
    02019.615.31E-041.71.3–2.216.115.00.90.7–1.2
    02021.33.78E-042.91.7–5.2
    03018.714.91E-051.81.4–2.411.518.63E-051.81.4–2.2
    040150.540.62E-040.70.5–0.8
    04026.44.80.70.5–1.014.96.87E-080.40.3–0.6
    15010.82.83E-043.71.9–7.2
    23011.30.25E-040.10.04–0.4
DPA1-DPB1
    0103-01012.50.87E-040.30.2–0.6
    0201-01017.08.21.20.9–1.6
    0103-02019.314.91E-041.71.4–2.214.914.71.00.8–1.3
    0103-02021.13.72E-043.41.9–6.3
    0103-03018.414.61–051.91.5–2.411.218.67E-061.81.4–2.3
    0103-040149.539.72E-040.70.5–0.835.138.11.11.0–1.4
    0103-04026.44.60.70.5–1.014.46.46E-080.40.3–0.6
    0103-23011.30.25E-050.10.04–0.4
    0104-15010.30.2–0.60.62.22E-033.71.7–7.9
  • DPA1, DPB1, and DPA1-DPB1 alleles and haplotypes with a frequency >5% in an individual category or >1% where the nominal P value was <0.05 were compared in the presence or absence of the following high-risk and protective DRB1-DQA1-DQB1 haplotype: 0301-0501-0201, 0401-0301-0302, 0402-0301-0302, 0404-0301-0302, 0405-0301-0302, 0701-0201-0303, 1401-0101-0503 and 1501-0102-0602. The nominal P value was adjusted (Padj) for multiple alleles or haplotypes by applying the Bonferroni correction of multiplying the nominal P value by the number of comparisons.