TABLE 4

DPA1-DPB1 haplotype frequency odds ratios for individual DRB1-DQA1-DQB1 haplotypes

DRB1-DQA1-DQB1Proband (n)AFBAC (n)DPA1-DPB1
0103-01010201-01010103-02010103-02020103-03010103-0402
ORPadjORORORPadjORPORPadj
04XX-0301-03021,3932391.41.60.7
0401-0301-03029091140.20.041.62.00.7
0402-0301-0302135362.21.90.5
0404-0301-0302223901.21.60.9
0301-0501-02011,2243420.25.E-060.81.52.50.041.70.45.E–03
A1-B8-DR34361460.30.81.93.50.031.20.030.40.04
A30-B18-DR399260.43.00.80.9
DR3 other6911700.15.E-060.81.52.21.30.5
0101-0101-05011952360.82.20.31.E–03
1302-0103-060493800.71.90.10.02
0701-0201-0201942701.01.10.3
1101-0501-0301321622.11.80.2
0401-0301-0301631112.20.4
  • The odds ratio (OR) was calculated for DPA–DPB1 haplotypes with a frequency >5% in an individual category or >1% where the nominal P value was <0.05. The nominal P value was adjusted (Padj) for multiple alleles or haplotypes by applying the Bonferroni correction of multiplying the nominal P value by the number of comparisons. DR3 (DRB1*0301-DQA1*0501-DQB1*0201) positive haplotypes were subdivided into the presence or absence of the extended A*0101-B*0801-C*0701-DRB1*0301-DQA1*0501-DQB1*0201 and A*3002-B*1801-C*0501-DRB1*0301-DQA1*0501-DQB1*0201 positive haplotypes.