TABLE 2

BMI-SDS at age 8 years in relation to fetal genotype in children of parents with type 1 diabetes

BMI-SDS, mean (95% CI)Effect per allele BMI-SDS (95% CI)§PP adjusted
Fetal genotype (no. of T2D risk alleles)
Locus012
HHEX-IDE0.25 (0.06–0.45)−0.04 (−0.15–0.08)−0.12 (−0.26–0.01)0.17 (0.06–0.28)0.0040.004
n = 104n = 318n = 218
CDKAL10.11 (−0.13–0.34)−0.05 (−0.17–0.07)−0.01 (−0.13–0.11)0.03 (−0.14–0.09)0.670.69
n = 74n = 284n = 88
SLC30A80.08 (−0.20–0.35)-0.09 (−0.21–0.03)0.02 (−0.09–0.14)0.03 (−0.09–0.16)0.600.54
n = 54n = 277n = 305
Birth weightSGAAGALGA
−0.33 (−0.57–0.10)−0.06 (−0.15–0.03)0.32 (0.15–0.49)<0.001<0.001
n = 70n = 507n = 132
  • §The association BMI-SDS and genotype for each SNP was examined using linear regression, with genotypes coded as 0, 1, or 2 risk alleles. The association BMI-SDS and birth weight was examined using linear regression, with birth weight coded as SGA (small for gestational age; <10th percentile), AGA (appropriate for gestational age; 10th–90th percentile), or LGA (large for gestational age; >90th percentile).

  • †Adjusted for proband (children who have a mother with type 1 diabetes or children without a mother with type 1 diabetes).