TABLE 1

Association of candidate SNPs with diabetic nephropathy in 4 independent Japanese populations

SNP (risk allele)* positionStudy 1Study 2Study 3Study 4
POR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)
rs39059 (A)0.111.14 (0.97–1.35)0.830.98 (0.84–1.15)0.031.93 (1.08–3.42)0.391.12 (0.87–1.43)
Ch7, 292554700.151.16 (0.95–1.43)0.881.01 (0.86–1.20)0.261.54 (0.72–3.28)0.830.97 (0.72–1.30)
rs39075 (G)0.231.11 (0.94–1.30)0.940.99 (0.85–1.16)0.071.72 (0.96–3.09)0.441.10 (0.86–1.41)
Ch7, 292766920.141.17 (0.95–1.43)0.771.03 (0.87–1.21)0.361.44 (0.66–3.14)0.710.95 (0.70–1.27)
rs1888747 (G)0.351.10 (0.90–1.36)0.860.98 (0.81–1.19)0.030.50 (0.27–0.93)0.120.79 (0.58–1.06)
Ch9, 861555510.101.24 (0.96–1.61)0.841.02 (0.83–1.26)0.0040.28 (0.12–0.67)0.430.87 (0.61–1.23)
rs10868025 (A)0.531.06 (0.88–1.28)0.410.93 (0.78–1.11)0.290.73 (0.40–1.31)0.260.86 (0.65–1.12)
Ch9, 861641760.311.12 (0.89–1.42)0.540.94 (0.78–1.14)0.070.49 (0.22–1.06)0.330.85 (0.62–1.18)
rs739401 (C)0.451.07 (0.90–1.28)0.850.98 (0.83–1.16)0.130.63 (0.34–1.15)0.690.95 (0.73–1.23)
Ch11, 30363240.301.12 (0.90–1.39)0.911.01 (0.85–1.21)0.250.62 (0.27–1.42)0.821.04 (0.76–1.42)
rs451041 (A)0.111.17 (0.97–1.41)0.601.05 (0.88–1.25)0.250.69 (0.36–1.31)0.860.98 (0.74–1.29)
Ch11, 30607250.0491.26 (1.00–1.59)0.421.08 (0.90–1.30)0.260.60 (0.25–1.46)0.911.02 (0.73–1.43)
rs1041466 (G)0.111.26 (0.95–1.66)0.511.11 (0.82–1.48)0.160.35 (0.08–1.50)0.920.98 (0.67–1.43)
Ch13, 1102443220.181.27 (0.90–1.80)0.181.27 (0.90–1.80)0.120.15 (0.01–1.59)0.441.20 (0.76–1.88)
rs1411766 (A)0.0451.33 (1.01–1.75)0.081.24 (0.98–1.56)0.750.86 (0.32–2.29)0.211.26 (0.88–1.82)
Ch13, 1102521600.0091.58 (1.12–2.22)0.081.26 (0.98–1.62)0.330.50 (0.12–2.01)0.0461.55 (1.01–2.39)
rs6492208 (T)0.611.05 (0.89–1.23)0.710.97 (0.83–1.14)0.681.13 (0.64–1.98)0.361.12 (0.88–1.43)
Ch13, 1102577260.740.97 (0.79–1.19)0.480.94 (0.79–1.11)0.820.91 (0.40–2.05)0.131.25 (0.93–1.67)
rs7989848 (A)0.751.03 (0.87–1.22)0.9991.00 (0.85–1.17)0.791.08 (0.60–1.95)0.111.23 (0.95–1.58)
Ch13, 1102834680.980.998 (0.81–1.23)0.600.96 (0.80–1.14)0.550.78 (0.34–1.78)0.031.42 (1.05–1.92)
rs9521445 (A)0.761.03 (0.87–1.22)0.751.03 (0.88–1.20)0.970.99 (0.55–1.78)0.091.25 (0.97–1.62)
Ch13, 1102855340.840.98 (0.79–1.21)0.820.98 (0.82–1.16)0.450.72 (0.30–1.69)0.021.45 (1.07–1.97)
  • *Risk allele reported in the GoKinD populations.

  • †Data from the National Center for Biotechnology Information database (Entrez SNP, Genome Reference Consortium Human Build 37.1; http://www.ncbi.nlm.nih.gov/sites/entrez?db=snp).

  • ‡Adjusted for age, sex, BMI, and duration of type 2 diabetes in studies 1, 3, and 4, and for age, sex, and BMI in study 2.