TABLE 2

Results of a meta-analysis of four independent Japanese studies on the association of 11 SNPs with diabetic nephropathy

SNP (risk allele)*Proteinuria (Studies 1, 2, and 3)Proteinuria + ESRD (all studies)
POR (95% CI)P for heterogeneityPOR (95% CI)P for heterogeneity
rs39059 (A)0.191.08 (0.96–1.20)0.060.121.08 (0.98–1.20)0.12
rs39075 (G)0.281.06 (0.95–1.19)0.180.191.07 (0.97–1.18)0.31
rs1888747 (G)0.991.00 (0.87–1.15)0.060.510.96 (0.85–1.09)0.05
rs10868025 (A)0.680.97 (0.86–1.10)0.370.400.95 (0.85–1.07)0.44
rs739401 (C)0.961.00 (0.89–1.13)0.240.910.99 (0.89–1.11)0.38
rs451041 (A)0.221.08 (0.95–1.23)0.260.301.06 (0.95–1.19)0.37
rs1041466 (G)0.161.15 (0.95–1.41)0.210.231.11 (0.93–1.33)0.29
rs1411766 (A)0.011.26 (1.06–1.50)0.690.0041.26 (1.07–1.47)0.86
rs6492208 (T)0.901.01 (0.90–1.13)0.780.621.03 (0.93–1.14)0.78
rs7989848 (A)0.821.01 (0.90–1.14)0.960.391.05 (0.94–1.16)0.59
rs9521445 (A)0.691.02 (0.91–1.15)0.990.291.06 (0.95–1.17)0.58
  • Meta-analysis was performed using the Mantel-Haenszel test.

  • *Risk allele reported in the GoKinD populations. ESRD, end-stage renal disease.