TABLE 3

Results of a meta-analysis of 4 independent Japanese studies and U.S.-GoKinD study on the association of 11 SNPs with diabetic nephropathy

SNP (risk allele)*Risk allele frequencies (case/control)Meta-analysis
Study 1Study 2Study 3Study 4GoKind*P for heterogeneityOriginal PCombined P
rs39059 (A)0.55/0.520.51/0.520.68/0.520.56/0.530.68/0.600.00996.7 × 10−60.038
rs39075 (G)0.55/0.520.53/0.530.68/0.560.57/0.550.65/0.570.0101.5 × 10−60.051
rs1888747 (G)0.81/0.800.80/0.800.70/0.820.77/0.810.74/0.665.8 × 10−51.3 × 10−60.912
rs10868025 (A)0.74/0.730.72/0.730.67/0.730.70/0.730.66/0.580.000271.1 × 10−60.851
rs739401 (C)0.33/0.320.33/0.330.28/0.390.32/0.330.55/0.480.00531.7 × 10−50.606
rs451041 (A)0.27/0.240.27/0.260.23/0.310.26/0.270.55/0.470.0338.1 × 10−60.166
rs1041466 (G)0.11/0.090.11/0.100.03/0.090.12/0.120.49/0.410.132.6 × 10−68.3 × 10−6
rs1411766 (A)0.12/0.090.13/0.110.09/0.100.15/0.120.39/0.320.771.9 × 10−64.9 × 10−8
rs6492208 (T)0.43/0.420.43/0.440.41/0.390.45/0.420.63/0.560.0155.4 × 10−60.152
rs7989848 (A)0.37/0.370.38/0.380.33/0.320.40/0.350.57/0.490.0321.2 × 10−50.084
rs9521445 (A)0.36/0.360.38/0.370.31/0.310.39/0.340.55/0.470.0263.7 × 10−60.072
  • Meta-analysis was performed using the Mantel-Haenszel test with a fixed-effects model, or the

  • ‡DerSimonian-Laird method with a random effect model.

  • *Risk allele reported in the GoKinD populations.

  • P values for allelic association model are calculated from the data in original report by Pezzolesi et al. (14).