TABLE 3

Steady-state, average isotope TTR of whole-blood 15N arginine; change (i.e., the slope) of whole-blood 15NOx TTR vs. time (dt, in min) (x 103); and their correlation coefficients (R); arginine Ra (in μmol/kg · min); and whole-blood average NOx concentrations (in μmol/l), in the basal state and after the hyperinsulinemic hyperglycemic clamp, in the type 2 diabetic and control subjects

BasalClamp
T2DM (n = 8)Control subjects (n = 10)T2DM (n = 8)Control subjects (n = 10)
15N-Arginine TTR3.24 ± 0.163.35 ± 0.214.41 ± 0.24§4.43 ± 0.18§
15NOx slopes0.438 ± 0.0900.520 ± 0.0980.688 ± 0.126*1.133 ± 0.166§
R of the 15NOx slopes0.92 ± 0.030.90 ± 0.020.92 ± 0.030.89 ± 0.02
Arginine flux1.13 ± 0.061.28 ± 0.050.84 ± 0.06§0.98 ± 0.04§
NOx concentrations81 ± 1162 ± 3665 ± 10128 ± 24§
  • *P < 0.05 and

  • §P < 0.015 or less, clamp vs. basal (by ANOVA, post hoc Tukey test).

  • P < 0.025 and

  • P < 0.01 or less, type 2 diabetic vs. control subjects (by ANOVA, either interaction or group effect). T2DM, type 2 diabetic subjects.