TABLE 2

Top 20 most differential regulated pathways out of 61

Pathway namet valueWestfall-Young adjusted P valueNo. of genes in pathway
GPCRDB_Class_A_Rhodopsin_like6.203137e-510.001174
Smooth_muscle_contraction1.882423e-480.001140
Calcium_regulation_in_cardiac_cells2.124932e-470.001135
Cell_cycle_KEGG2.704092e-470.00187
Peptide_GPCRs3.017272e-470.00172
Insulin_signaling1.348158e-440.001142
GPCRDB_Other2.606078e-430.00170
Ribosomal_Proteins8.182642e-430.001109
Integrin-mediated_cell_adhesion9.481823e-430.00189
G_Protein_Signaling2.189569e-410.00186
mRNA processing Reactome1.481700e-390.001105
G1 to S cell cycle Reactome6.158349e-390.00165
Electron transport chain7.287427e-390.00188
Apoptosis6.909579e-370.00168
Proteasome Degradation2.345890e-300.00161
Matrix Metalloproteinases2.799155e-110.00132
Wnt signaling4.641920e-110.00157
Glycolysis and Gluconeogenesis1.093909e-100.00147
TGF beta Signaling Pathway1.504555e-100.00148
Striated muscle contraction8.382124e-100.00133
  • Results are ranked according to significance (t values from multivariate Westfall-Young analysis).