TABLE 3

Geometric mean levels of total estradiol, total testosterone, and DHEAS according to caffeinated coffee, decaffeinated coffee, tea, and caffeine consumption

0 cups/day≤1 cups/day2–3 cups/day≥4 cups/dayP for trend
Caffeinated coffee, median (n)0 (185)1.0 (187)2.5 (212)4.5 (122)
    Total estradiol (pg/ml)23.6 (17.9–31.1)21.2 (16.1–28.1)23.9 (18.0–31.6)22.0 (16.5–29.2)0.76
    Total testosterone (ng/dl)20.7 (13.4–32.0)21.5 (13.8–33.3)22.8 (14.6–35.4)22.3 (14.3–35.0)0.23
    DHEAS (μg/dl)87.8 (57.6–133.7)89.0 (58.2–136.1)94.4 (61.6–144.6)93.3 (60.4–144.0)0.28
Decaffeinated coffee, median (n)0 (401)0.4 (188)2.5 (84)4.5 (23)
    Total estradiol (pg/ml)23.0 (17.4–30.5)21.6 (16.2–28.8)22.7 (16.8–30.8)21.8 (15.7–30.3)0.67
    Total testosterone (ng/dl)21.0 (13.6–32.4)18.7 (11.9–29.2)19.7 (12.3–31.6)19.9 (11.9–33.3)0.55
    DHEAS (μg/dl)86.3 (56.5–131.8)83.1 (53.8–128.5)84.5 (53.5–133.6)88.5 (53.7–145.6)0.99
Tea, median (n)0 (242)0.4 (351)2.5 (76)4.5 (28)
    Total estradiol (pg/ml)22.9 (17.3–30.2)23.5 (17.8–31.1)24.6 (18.5–32.7)22.4 (16.3–30.8)0.60
    Total testosterone (ng/dl)21.7 (14.1–33.6)23.0 (14.8–35.6)21.9 (14.0–34.3)19.7 (11.9–32.4)0.49
    DHEAS (μg/dl)87.8 (57.7–133.5)94.9 (62.2–144.8)88.2 (57.2–136.1)78.1 (48.3–126.2)0.36
Caffeine category (mg/day)<5050–249250–499≥500
Caffeine intake, median (mg/day) (n)13 (131)140 (209)366 (230)656 (123)
    Total estradiol (pg/ml)23.0 (17.4–30.4)22.4 (16.9–29.5)24.2 (18.3–32.0)22.4 (16.9–29.8)0.79
    Total testosterone (ng/dl)19.4 (12.5–30.0)21.9 (14.2–33.8)22.1 (14.2–34.2)22.1 (14.2–34.5)0.21
    DHEAS (μg/dl)84.2 (55.1–128.7)90.2 (59.1–137.6)92.3 (60.3–141.3)90.5 (58.7–139.5)0.42
  • Data are geometric means (95% CI).

  • *P for trend are based on median values in categories of the participants. All models were adjusted for matching factors (age, race, duration of follow-up, and time of blood draw), smoking status, physical activity, alcohol use, total calories, and BMI.