TABLE 3

Baseline associations between each SNP and fasting and 2-h glucose concentrations (n = 16,330)

SNPNearest gene (s)Effect allele (other)Effect allele frequencyFasting glucose (mmol/l)2-h glucose (mmol/l)
Effect (SE)*P*Effect (SE)*P*Effect (SE)P
rs10830963MTNR1BG(C)0.280.091 (0.008)2.7 × 10−310.013 (0.019)0.49−0.042 (0.018)0.02
rs560887G6PC2C(T)0.710.063 (0.008)1.9 × 10−160.013 (0.018)0.47−0.025 (0.018)0.16
rs4607517GCKA(G)0.150.054 (0.010)3.1 × 10−80.083 (0.023)3.9 × 10−40.050 (0.023)0.03
rs11605924CRY2A(C)0.500.033 (0.007)1.5 × 10−60.062 (0.017)2.0 × 10−40.042 (0.016)9.1 × 10−3
rs2191349DGKB-TMEM195T(G)0.510.029 (0.007)2.7 × 10−50.007 (0.017)0.69−0.009 (0.016)0.56
rs13266634SLC30A8C(T)0.700.029 (0.008)1.4 × 10−40.044 (0.018)0.020.027 (0.017)0.12
rs780094GCKRC(T)0.710.025 (0.008)1.1 × 10−3−0.024 (0.018)0.20−0.039 (0.018)0.03
rs7903146TCF7L2T(C)0.200.028 (0.009)1.2 × 10−30.084 (0.021)6.9 × 10−50.066 (0.020)1.2 × 10−3
rs10885122ADRA2AG(T)0.890.035 (0.011)1.5 × 10−3−0.004 (0.026)0.89−0.024 (0.026)0.36
rs174550FADS1T(C)0.660.019 (0.007)9.7 × 10−30.035 (0.017)0.040.024 (0.017)0.15
rs11920090SLC2A2T(A)0.860.026 (0.010)9.7 × 10−30.057 (0.024)0.020.040 (0.023)0.09
rs340874PROX1C(T)0.530.016 (0.007)0.020.016 (0.017)0.330.006 (0.016)0.69
rs7944584MADDA(T)0.760.014 (0.008)0.100.011 (0.020)0.570.003 (0.019)0.86
rs7034200GLIS3A(C)0.430.009 (0.007)0.180.003 (0.017)0.88−0.004 (0.016)0.80
rs11708067ADCY5A(G)0.790.010 (0.009)0.240.087 (0.021)2.4 × 10−50.080 (0.020)5.7 × 10−5
rs11071657C2CD4BA(G)0.600.007 (0.007)0.35−0.035 (0.017)0.04−0.041 (0.016)0.01
  • SNPs are ranked by P value for the association with fasting glucose concentrations. Multiple testing was corrected for using the Holm procedure (29). All genotypes are located on the plus strand and coded according to HapMap CEU (phase II + III), release 27, National Center for Biotechnology Information build 36. Two-hour glucose concentrations were measured by a 75-g oral glucose tolerance test in accordance with the World Health Organization guidelines (21).

  • *Adjusted for age, sex, and fasting time.

  • †Adjusted for age, sex, fasting time, and fasting glucose concentrations.