TABLE 5

Cross-sectional and longitudinal associations between each SNP and IFG

SNPNearest gene(s)Effect allele (freq.)Cross-sectional§Longitudinal
OR95% CIOR95% CI
rs10830963MTNR1BG (0.28)1.31(1.24–1.38)*1.17(1.05–1.30)*
rs560887G6PC2C (0.71)1.21(1.15–1.28)*1.13(1.02–1.25)*
rs4607517GCKA (0.15)1.19(1.11–1.27)*1.13(0.99–1.29)
rs10885122ADRA2AG (0.89)1.13(1.05–1.22)*1.16(0.99–1.35)
rs2191349DGKB-TMEM195T (0.51)1.11(1.05–1.16)*1.09(0.99–1.20)
rs7903146TCF7L2T (0.20)1.11(1.05–1.18)*1.08(0.96–1.22)
rs13266634SLC30A8T (0.70)1.10(1.05–1.16)*1.05(0.95–1.17)
rs11605924CRY2A (0.50)1.09(1.04–1.14)*1.09(0.99–1.20)
rs780094GCKRC (0.72)1.08(1.02–1.13)*0.92(0.83–1.02)
rs11920090SLC2A2T (0.86)1.06(0.99–1.13)1.11(0.96–1.28)
rs7034200GLIS3A (0.43)1.05(1.00–1.10)*1.02(0.93–1.12)
rs11708067ADCY5A (0.80)1.05(0.99–1.12)0.99(0.87–1.11)
rs340874PROX1C (0.53)1.04(0.99–1.09)1.12(1.02–1.24)*
rs174550FADS1T (0.66)1.04(0.98–1.09)1.08(0.97–1.19)
rs7944584MADDA (0.76)1.04(0.98–1.10)1.00(0.89–1.12)
rs11071657C2CD4BA (0.60)1.01(0.96–1.06)1.02(0.92–1.13)
  • Main effects are expressed as odds ratios (ORs) (IFG vs. normal glucose regulation) per copy of the effect allele at each locus ranked by effect size on baseline association with IFG.

  • §Models adjusted for age, sex, and fasting time (n = 16,330).

  • †Models adjusted for age and sex, fasting times at baseline and follow-up, follow-up time, and baseline IFG (n = 4,059).

  • *P < 0.05.