TABLE 2

Changes in anthropometric variables at conclusion of the randomized phase

CharacteristicMetforminPlaceboDifferenceP
N5347
BMI SD score−0.11 (−0.16 to −0.05)−0.04 (−0.1 to 0.02)−0.07 (−0.12 to −0.01)0.02
BMI (kg/m2)−0.78 (−1.54 to −0.01)0.32 (−0.54 to 1.18)−1.09 (−1.87 to −0.31)0.006
Weight (kg)1.47 (−0.31 to 3.24)4.85 (2.84 to 6.85)−3.38 (−5.2 to −1.57)<0.001
Fat mass by DEXA (kg)0.48 (−0.80 to 1.76)1.88 (0.44 to 3.31)−1.40 (−2.74 to −0.06)0.04
Fat mass by air displacement plethysmography (kg)−1.51 (−4.56 to 1.54)1.81 (−1.64 to 5.25−3.32 (−6.49 to −0.14)0.04
Abdominal circumference (cm)1.84 (−1 to 4.69)4.38 (1.23 to 7.53)−2.54 (−4.57 to −0.5)0.02
Hip circumference (cm)−0.44 (−2.76 to 1.87)1.84 (−0.72 to 4.41)−2.29 (−3.97 to −0.6)0.009
Triceps skinfold thickness (mm)−2.64 (−6.79 to 1.5)1.65 (−2.94 to 6.24)−4.29 (−7.28 to −1.3)0.006
Abdominal adipose tissue (cc)
 L2–3 subcutaneous7.4 (−25.7 to 40.5)22.7 (−13.7 to 59.1)−15.3 (−37.6 to 7.1)0.18
 L4–5 subcutaneous−21.6 (−55 to 11.7)1.0 (−35.6 to 37.7)−22.7 (−45.1 to −0.2)0.05
 L2–3 intra-abdominal2.5 (−26.1 to 31.0)8.5 (−23.0 to 40.0)−5.9 (−25.3 to 13.4)0.54
 L4–5 intra-abdominal2.1 (−19.7 to 23.8)4.4 (−19.5 to 28.3)−2.3 (−17 to 2.4)0.76
Systolic blood pressure SD score0.20 (−0.88 to 1.28)−0.17 (−1.38 to 1.05)0.37 (−0.54 to 1.28)0.42
Diastolic blood pressure SD score−0.02 (−0.67 to 0.62)−0.19 (−0.91 to 0.54)0.16 (−0.38 to 0.7)0.56
  • Estimated marginal means (95% CIs), adjusted for covariates, were reported from multiple imputation analyses.