TABLE 3

Meta-analysis results of observed and instrumental variable analyses of triglyceride–continuous outcome associations

TraitObserved change in outcome z score per 1-SD increase in log10-triglyceridesInstrumental variable estimate of change in outcome z score per 1-SD increase in log10-triglycerides
Effect size (95% CI)PHeterogeneity P (I2%)Effect size (95% CI)PHeterogeneity P (I2%)
Fasting insulin0.41 (0.38–0.43)<0.0010.008 (74.6)0.04 (−0.08 to 0.16)0.490.12 (48.2)
Fasting glucose0.12 (0.10–0.15)<0.0010.02 (69.5)0.01 (−0.10 to 0.12)0.900.002 (79.4)
HOMA-IR0.40 (0.38–0.42)<0.0010.006 (75.7)0.04 (−0.08 to 0.16)0.510.13 (47.3)
HOMA-B0.36 (0.33–0.38)<0.0010.11 (49.7)0.01 (−0.11 to 0.13)0.830.27 (23.7)
  • The sample sizes for the triglyceride vs. outcome associations ranged from 6,705 to 8,227 and from 6,519 to 8,040 for instrumental variable meta-analyses.