Trait | Observed change in outcome z score per 1-SD increase in log_{10}-triglycerides | Instrumental variable estimate of change in outcome z score per 1-SD increase in log_{10}-triglycerides | ||||
---|---|---|---|---|---|---|

Effect size (95% CI) | P | Heterogeneity P (I^{2}%) | Effect size (95% CI) | P | Heterogeneity P (I^{2}%) | |

Fasting insulin | 0.41 (0.38–0.43) | <0.001 | 0.008 (74.6) | 0.04 (−0.08 to 0.16) | 0.49 | 0.12 (48.2) |

Fasting glucose | 0.12 (0.10–0.15) | <0.001 | 0.02 (69.5) | 0.01 (−0.10 to 0.12) | 0.90 | 0.002 (79.4) |

HOMA-IR | 0.40 (0.38–0.42) | <0.001 | 0.006 (75.7) | 0.04 (−0.08 to 0.16) | 0.51 | 0.13 (47.3) |

HOMA-B | 0.36 (0.33–0.38) | <0.001 | 0.11 (49.7) | 0.01 (−0.11 to 0.13) | 0.83 | 0.27 (23.7) |

The sample sizes for the triglyceride vs. outcome associations ranged from 6,705 to 8,227 and from 6,519 to 8,040 for instrumental variable meta-analyses.