TABLE 1

Suggestive (LOD >2.2) and significant (LOD >3.6) loci from genome linkage scans of the T1DGC family collections

FamiliesPosition (cM)LODPLOD-1 support intervalReported in T1DGC sets 1 and 2 (4,5)
T1DGC set 3
 Chromosomes
  6p2152.5135.751.0–52.5Yes
  6q1492.75.1*90.7–93.3Yes
  6q1595.76.2*93.3–98.1Yes
  6q22123.13.23*0.00006120.5–126.9No
  8p1252.72.40.000448.8–60.9No
  11p151.052.740.00030–4.7Yes
Sets 1, 2, and 3
 Chromosomes
  2q13123.82.680.0002120.3–126.8No
  2q31194.23.110.00008191.8–193.8Yes
  6p2152.0398.651.5–52.5Yes
  8q2195.52.650.000293.5–101.5No
  11p152.55.530–5.0Yes
  19q1358.03.300.0000554.5–63.5Yes
  • Summary of linkage analyses for the third and final set of T1DGC families. Positions of LOD score peaks are shown for the chromosome band (taken from www.t1dbase.org for the nearest SNP) and cM position. P values shown for LODs <5.

  • *LOD scores on chromosome 6q were adjusted for HLA linkage by subtracting the ELOD (see text). Peaks were defined as points at least 1 LOD unit above the surrounding linkage plot; the additional families in the combined dataset obscured the separable peaks observed on chromosomes 6q14 and 6q15 in set 3 alone.