TABLE 1

Heart rate and blood pressure responses on day 1 during clamped hyperinsulinemic euglycemia (0800–0900 h) and hypoglycemia (0900–1100 h)

SalinePTL + PRPPTL + PRP + Atropine
HRsBPdBPHRsBPdBPHRsBPdBP
Clock time(bpm)(mmHg)(mmHg)(bpm)(mmHg)(mmHg)(bpm)(mmHg)(mmHg)
0745 h69 ± 3125 ± 372 ± 269 ± 2120 ± 368 ± 267 ± 3119 ± 367 ± 2
0800 h68 ± 2125 ± 371 ± 270 ± 2118 ± 466 ± 269 ± 3118 ± 368 ± 2
0815 h70 ± 2124 ± 370 ± 371 ± 2117 ± 363 ± 271 ± 3114 ± 364 ± 2
0830 h71 ± 3125 ± 370 ± 272 ± 2115 ± 360 ± 169 ± 3112 ± 364 ± 2
0845 h70 ± 2124 ± 370 ± 269 ± 2112 ± 360 ± 269 ± 2111 ± 360 ± 2
0900 h71 ± 2124 ± 368 ± 268 ± 2113 ± 358 ± 177 ± 4112 ± 359 ± 2
0915 h71 ± 2125 ± 469 ± 369 ± 2111 ± 357 ± 290 ± 3111 ± 362 ± 2
0930 h72 ± 3124 ± 468 ± 367 ± 2110 ± 357 ± 286 ± 3113 ± 360 ± 2
0945 h74 ± 3123 ± 465 ± 367 ± 2110 ± 355 ± 282 ± 3110 ± 358 ± 2
1000 h76 ± 3126 ± 464 ± 266 ± 2108 ± 253 ± 182 ± 2109 ± 357 ± 2
1015 h73 ± 2125 ± 363 ± 366 ± 2109 ± 352 ± 286 ± 2109 ± 355 ± 2
1030 h73 ± 2122 ± 461 ± 363 ± 2105 ± 352 ± 184 ± 2106 ± 353 ± 2
1045 h72 ± 3122 ± 460 ± 260 ± 2106 ± 351 ± 180 ± 2106 ± 351 ± 2
1145 h73 ± 3119 ± 460 ± 260 ± 2106 ± 351 ± 177 ± 2105 ± 351 ± 2
Pvs. saline<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001
  • Values are mean ± SE.

  • dBP, diastolic blood pressure; HR, heart rate; sBP, systolic blood pressure; PTL, phentolamine; PRP, propranolol.