TABLE 3

Association of mean A1C in combined treatment groups during DCCT and EDIC with change in common carotid IMT over EDIC years 1, 6, and 12*

Change in carotid intima-media thickness
Years 1 to 6 (mm)Years 6 to 12 (mm)Years 1 to 12 (mm)
Mean A1Cβ-coefficientPβ-coefficientPβ-coefficientP
DCCT0.0074 ± 0.0018<0.00010.0038 ± 0.00230.10520.0087 ± 0.00260.0008
DCCT/EDIC to year 10.0079 ± 0.0020<0.00010.0045 ± 0.00250.06940.0097 ± 0.00280.0006
EDIC years 1 to 6, mean0.0042 ± 0.00210.04970.0071 ± 0.00270.00750.0084 ± 0.00300.0049
DCCT/EDIC to year 60.0082 ± 0.00230.00030.0068 ± 0.00280.01750.0115 ± 0.00320.0003
EDIC years 1 to 12N/AN/A0.0083 ± 0.00290.00390.0103 ± 0.00320.0016
DCCT/EDIC to year 12N/AN/A0.0086 ± 0.00310.00560.0132 ± 0.00350.0002
  • N/A, not applicable.

  • *Separate multiple linear regression models for the change in IMT over each period adjusted for age, sex, study cohort, IMT reader, and image device. Change from years 1 to 6 and change from years 1 to 12 models also adjusted for the year 1 IMT. Change from years 6 to 12 model also adjusted for the year 6 IMT. Separate models with each different A1C measure were performed.

  • †The β-coefficient (estimated ± SE) is the millimeter change in IMT progression per whole % greater A1C.

  • ‡Weighted mean of DCCT and EDIC A1C values over time, each weighted by the interval of time between values 3 months for each DCCT quarterly A1C value, 12 months for each EDIC annual A1C value.