TABLE 2

Plasma concentrations during steady state

Lean control subjectsObese type 2 diabetic subjects
ArteryHepatic veinArteryHepatic vein
Cortisol (nmol/L)222 ± 19210 ± 24213 ± 9213 ± 10
d3-Cortisol (nmol/L)64 ± 1072 ± 12*59 ± 466 ± 5
d4-Cortisol (nmol/L)69 ± 953 ± 854 ± 242 ± 2
Cortisone (nmol/L)35 ± 27 ± 236 ± 28 ± 2
D3-Cortisone (nmol/L)14 ± 11.0 ± 0.714 ± 10.7 ± 0.6
  • Data are means ± SEM for lean control subjects (n = 7) and obese patients with diabetes (n = 10 for arterial veins, n = 9 for hepatic veins) for the mean of measurements taken between 180 and 210 min of the deuterated cortisol infusion.

  • *P < 0.05;

  • P < 0.001 vs. arterialized measurements within groups. Plasma steroid concentrations were not different between groups.